ArticleBiophysical journal2006
Dielectric measurement of individual microtubules using the electroorientation method.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- How augmin establishes the angle of the microtubule branch site.Nature communications · 2025Article
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- Protein Manipulation via Dielectrophoresis: Theoretical Principles and Emerging Microfluidic Platforms.Micromachines · 2025Review
- Raman Spectroscopy Reveals Photobiomodulation-Induced α-Helix to β-Sheet Transition in Tubulins: Potential Implications for Alzheimer's and Other Neurodegenerative Diseases.Nanomaterials (Basel, Switzerland) · 2024Article
- [Study on the mesoscopic dynamic effects of tumor treating fields on cell tubulin].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Article
- Electrodynamic interaction between tumor treating fields and microtubule electrophysiological activities.APL bioengineering · 2024Article
- A novel conductive microtubule hydrogel for electrical stimulation of chronic wounds based on biological electrical wires.Journal of nanobiotechnology · 2024Article
- Article
- Brain Microtubule Electrical Oscillations-Empirical Mode Decomposition Analysis.Cellular and molecular neurobiology · 2023Article
- Monte Carlo simulation and experimental validation of plant microtubules cathode in biodegradable battery.Scientific reports · 2023Article
- The electrical properties of isolated microtubules.Scientific reports · 2023Article
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- Transcranial Electromagnetic Treatment Stops Alzheimer's Disease Cognitive Decline over a 2½-Year Period: A Pilot Study.Medicines (Basel, Switzerland) · 2022Article
- Biosynthesis of Linear Protein Nanoarrays Using the Flagellar Axoneme.ACS synthetic biology · 2022Article
- Calcium signal transmission by axonemal microtubules as an optimized information pathway in cilia and flagella.Journal of bioenergetics and biomembranes · 2021Article
- Modeling Microtubule Counterion Distributions and Conductivity Using the Poisson-Boltzmann Equation.Frontiers in molecular biosciences · 2021Article
- Tumor Treating Fields (TTFields) Hinder Cancer Cell Motility through Regulation of Microtubule and Acting Dynamics.Cancers · 2020Article
- Calcium signaling modulates the dynamics of cilia and flagella.European biophysics journal : EBJ · 2020Article
- Voltage-gated ion channels mediate the electrotaxis of glioblastoma cells in a hybrid PMMA/PDMS microdevice.APL bioengineering · 2020Article
- A Confirmation for the Positive Electric Charge of Bio-Molecular Motors through Utilizing a Novel Nano-Technology Approach In Vitro.International journal of molecular sciences · 2020Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Little is known about the electrostatic/dynamic properties of microtubules, which are considered to underlie their electrostatic interactions with various proteins such as motor proteins, microtubule-associated proteins, and microtubules themselves (lateral association of microtubules). To measure the dielectric properties of microtubules, we developed an experiment system in which the electroorientation of microtubules was observed under a dark-field microscope. Upon application of an alternating electric field (0.5-1.9 x 10(5) V/m, 10 kHz-3 MHz), the microtubules were oriented parallel to the field line in a few seconds because of the dipole moment induced along their long axes. The process of this orientation was analyzed based on a dielectric ellipsoid model, and the conductivity and dielectric constant of each microtubule were calculated. The analyses revealed that the microtubules were highly conductive, which is consistent with the counterion polarization model-counterions bound to highly negatively charged microtubules can move along the long axis, and this mobility might be the origin of the high conductivity. Our experiment system provides a useful tool to quantitatively evaluate the polyelectrolyte nature of microtubules, thus paving the way for future studies aiming to understand the physicochemical mechanism underlying the electrostatic interactions of microtubules with various proteins.
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