ArticleJournal of molecular biology2006
Crystal structure of the murine cytomegalovirus MHC-I homolog m144.
Article in Journal of molecular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- MHC in newts illuminates the evolutionary dynamics of complex regions in giant genomes.Genome research · 2026Article
- Oncolytic α-herpesvirus and myeloid-tropic cytomegalovirus cooperatively enhance systemic antitumor responses.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Herpesvirus Evasion of Natural Killer Cells.Journal of virology · 2018Review
- Herpesviral capture of immunomodulatory host genes.Virus genes · 2017Review
- The evolution of natural killer cell receptors.Immunogenetics · 2016Review
- The structure of mouse cytomegalovirus m04 protein obtained from sparse NMR data reveals a conserved fold of the m02-m06 viral immune modulator family.Structure (London, England : 1993) · 2014Article
- The structure of the cytomegalovirus-encoded m04 glycoprotein, a prototypical member of the m02 family of immunoevasins.The Journal of biological chemistry · 2014Article
- Know Thyself: NK-Cell Inhibitory Receptors Prompt Self-Tolerance, Education, and Viral Control.Frontiers in immunology · 2014Review
- Crystal structure of the cowpox virus-encoded NKG2D ligand OMCP.Journal of virology · 2013Article
- Structural basis of mouse cytomegalovirus m152/gp40 interaction with RAE1γ reveals a paradigm for MHC/MHC interaction in immune evasion.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Self or nonself? That is the question: sensing of cytomegalovirus infection by innate immune receptors.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Review
- How the virus outsmarts the host: function and structure of cytomegalovirus MHC-I-like molecules in the evasion of natural killer cell surveillance.Journal of biomedicine & biotechnology · 2011Review
- Human herpesvirus 7 u21 downregulates classical and nonclassical class I major histocompatibility complex molecules from the cell surface.Journal of virology · 2010Article
- Investigating homology between proteins using energetic profiles.PLoS computational biology · 2010Article
- Direct interaction of the mouse cytomegalovirus m152/gp40 immunoevasin with RAE-1 isoforms.Biochemistry · 2010Article
- Feeling manipulated: cytomegalovirus immune manipulation.Virology journal · 2009Article
- Structure and function of murine cytomegalovirus MHC-I-like molecules: how the virus turned the host defense to its advantage.Immunologic research · 2009Article
- Cellular expression and crystal structure of the murine cytomegalovirus major histocompatibility complex class I-like glycoprotein, m153.The Journal of biological chemistry · 2007Article
- Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Structural basis for recognition of MHC and MHC-like ligands by natural killer cell receptors.Seminars in immunology · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Large DNA viruses of the herpesvirus family produce proteins that mimic host MHC-I molecules as part of their immunoevasive strategy. The m144 glycoprotein, expressed by murine cytomegalovirus, is thought to be an MHC-I homolog whose expression prolongs viral survival in vivo by preventing natural killer cell activation. To explore the structural basis of this m144 function, we have determined the three-dimensional structure of an m144/beta2-microglobulin (beta2m) complex at 1.9A resolution. This structure reveals the canonical features of MHC-I molecules including readily identifiable alpha1, alpha2, and alpha3 domains. A unique disulfide bond links the alpha1 helix to the beta-sheet floor, explaining the known thermal stability of m144. Close juxtaposition of the alpha1 and alpha2 helices and the lack of critical residues that normally contribute to anchoring the peptide N and C termini eliminates peptide binding. A region of 13 amino acid residues, corresponding to the amino-terminal portion of the alpha2 helix, is missing in the electron density map, suggesting an area of structural flexibility that may be involved in ligand binding.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.