ArticleDevelopmental biology2006
Epithelial overexpression of BDNF and NT4 produces distinct gustatory axon morphologies that disrupt initial targeting.
Article in Developmental biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 45 citations in OpenAlex.
- Developing and regenerating a sense of taste.Current topics in developmental biology · 2025Review
- Give-and-take of gustation: the interplay between gustatory neurons and taste buds.Chemical senses · 2024Review
- Interleukin (IL)-1 Receptor Signaling Is Required for Complete Taste Bud Regeneration and the Recovery of Neural Taste Responses following Axotomy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- SOX2-Sensing: Insights into the Role of SOX2 in the Generation of Sensory Cell Types in Vertebrates.International journal of molecular sciences · 2023Review
- Wiring the senses: Factors that regulate peripheral axon pathfinding in sensory systems.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Review
- Reciprocal signals between nerve and epithelium: how do neurons talk with epithelial cells?American journal of stem cells · 2021Review
- Hedgehog Signaling Regulates Taste Organs and Oral Sensation: Distinctive Roles in the Epithelium, Stroma, and Innervation.International journal of molecular sciences · 2019Review
- TrkB expression and dependence divides gustatory neurons into three subpopulations.Neural development · 2019Article
- The emerging role of cranial nerves in shaping craniofacial development.Genesis (New York, N.Y. : 2000) · 2019Review
- The transcription factor Phox2b distinguishes between oral and non-oral sensory neurons in the geniculate ganglion.The Journal of comparative neurology · 2017Article
- Taste bud-derived BDNF maintains innervation of a subset of TrkB-expressing gustatory nerve fibers.Molecular and cellular neurosciences · 2017Article
- BDNF is required for taste axon regeneration following unilateral chorda tympani nerve section.Experimental neurology · 2017Article
- Ephrin-B/EphB Signaling Is Required for Normal Innervation of Lingual Gustatory Papillae.Developmental neuroscience · 2016Article
- Postnatal reduction of BDNF regulates the developmental remodeling of taste bud innervation.Developmental biology · 2015Article
- Shrinkage of ipsilateral taste buds and hyperplasia of contralateral taste buds following chorda tympani nerve transection.Neural regeneration research · 2015Article
- Expanded terminal fields of gustatory nerves accompany embryonic BDNF overexpression in mouse oral epithelia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The neurotrophin receptor p75 regulates gustatory axon branching and promotes innervation of the tongue during development.Neural development · 2014Article
- Roles of innervation in developing and regenerating orofacial tissues.Cellular and molecular life sciences : CMLS · 2014Review
- BDNF and NT4 play interchangeable roles in gustatory development.Developmental biology · 2014Article
- Neurotrophin-4 regulates the survival of gustatory neurons earlier in development using a different mechanism than brain-derived neurotrophic factor.Developmental biology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Most fungiform taste buds fail to become innervated when BDNF or NT4 is overexpressed in the basal layer of tongue epithelium. Here, we examined when and how overexpression of BDNF and NT4 disrupt innervation to fungiform papillae. Overexpression of either factor disrupted chorda tympani innervation patterns either before or during the initial innervation of fungiform papillae. NT4 and BDNF overexpression each disrupted initial innervation by producing different gustatory axon morphologies that emerge at distinct times (E12.5 and E14.5, respectively). Chorda tympani nerve branching was reduced in NT4 overexpressing mice, and neuronal fibers in these mice were fasciculated and remained below the epithelial surface, as if repelled by NT4 overexpression. In contrast, many chorda tympani nerve branches were observed near the epithelial surface in mice overexpressing BDNF, and most were attracted to and invaded non-taste filiform papillae instead of gustatory papillae. These results suggest that BDNF, but not NT4, normally functions as a chemoattractant that allows chorda tympani fibers to distinguish their fungiform papillae targets from non-gustatory epithelium. Since BDNF and NT4 both signal through the p75 and TrkB receptors, trophin-specific activation of different internal signaling pathways must regulate the development of the distinct gustatory axon morphologies in neurotrophin-overexpressing mice.
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