ArticleBiochemical and biophysical research communications2006
Upregulation of ICOS on CD43+ CD4+ murine small intestinal intraepithelial lymphocytes during acute reovirus infection.
Article in Biochemical and biophysical research communications, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Pembrolizumab in Combination with the Oncolytic Virus Pelareorep and Chemotherapy in Patients with Advanced Pancreatic Adenocarcinoma: A Phase Ib Study.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020Article
- Involvement of Ly6C, 4-1BB, and KLRG1 in the activation of lamina propria lymphocytes in the small intestine of sanroque mice.Biochemical and biophysical research communications · 2017Article
- Soluble gp130 promotes intestinal epithelial hyperplasia during reovirus infection.International journal of experimental pathology · 2010Article
- ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10-/- mice.Journal of leukocyte biology · 2010Article
- Bone marrow cells produce a novel TSHbeta splice variant that is upregulated in the thyroid following systemic virus infection.Genes and immunity · 2009Article
- Virus infection activates thyroid stimulating hormone synthesis in intestinal epithelial cells.Journal of cellular biochemistry · 2008Article
- Stimulatory and costimulatory effects of IL-18 directed to different small intestinal CD43 T cell subsets.Journal of leukocyte biology · 2007Article
- T-cell activation in the intestinal mucosa.Immunological reviews · 2007Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Murine intestinal intraepithelial lymphocytes (IELs) can be classified according to expression of a CD43 glycoform recognized by the S7 monoclonal antibody. In this study, we examined the response of S7+ and S7- IELs in mice during acute reovirus serotype 3 (Dearing strain) infection, which was confirmed by virus-specific real-time PCR. In vivo proliferation increased significantly for both S7- and S7+ IELs on day 4 post-infection as determined by BrdU incorporation; however, expression of the inducible costimulatory (ICOS) molecule, which peaked on day 7 post-infection, was upregulated on S7+ CD4+ T cells, most of which were CD4+8- IELs. In vitro ICOS stimulation by syngeneic peritoneal macrophages induced IFN-gamma secretion from IELs from day 7 infected mice, and was suppressed by treatment with anti-ICOS mAb. Additionally, IFN-gamma mRNA increased in CD4+ IELs on day 6 post-infection. These findings indicate that S7- and S7+ IELs are differentially mobilized during the immune response to reovirus infection; that the regulated expression of ICOS is associated with S7+ IELs; and that stimulation of IELs through ICOS enhances IFN-gamma synthesis during infection.
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