ReviewThe Lancet. Infectious diseases2006
Bacterial pneumonia vaccines and childhood pneumonia: are we winning, refining, or redefining?
Review in The Lancet. Infectious diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01766206 (A Multicenter Post Marketing Surveillance Study to Monitor the Safety of GlaxoSmithKline), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicenter Post Marketing Surveillance Study to Monitor the Safety of GlaxoSmithKline (GSK) Biologicals' Meningococcal ACWY Conjugate Vaccine(MenACWY-CRM) Administered According to the Prescribing Information to Healthy Subjects From 2 Months to 55 Years of Age in the Republic of South Korea.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Dose-specific efficacy of Haemophilus influenzae type b conjugate vaccines: a systematic review and meta-analysis of controlled clinical trials.Epidemiology and infection · 2012Pooled it
- Recommendations for treatment of childhood non-severe pneumonia.The Lancet. Infectious diseases · 2009Guideline
- Article
- Concatenated Modified LeNet Approach for Classifying Pneumonia Images.Journal of personalized medicine · 2024Article
- Pulmonary Diseases in Older Patients: Understanding and Addressing the Challenges.Geriatrics (Basel, Switzerland) · 2024Article
- Mechanisms of Lung and Intestinal Microbiota and Innate Immune Changes Caused by Pathogenic Enterococcus Faecalis Promoting the Development of Pediatric Pneumonia.Microorganisms · 2023Article
- Probiotic-based nanoparticles for targeted microbiota modulation and immune restoration in bacterial pneumonia.National science review · 2023Article
- Role of lung ultrasound for the etiological diagnosis of acute lower respiratory tract infection (ALRTI) in children: a prospective study.Journal of ultrasound · 2022Article
- Chest X-ray Classification for the Detection of COVID-19 Using Deep Learning Techniques.Sensors (Basel, Switzerland) · 2022Article
- Streptococcus Pneumoniae-Associated Hemolytic Uremic Syndrome in the Era of Pneumococcal Vaccine.Pathogens (Basel, Switzerland) · 2021Review
- Pneumonia Classification Using Deep Learning from Chest X-ray Images During COVID-19.Cognitive computation · 2021Article
- New insights into the pathogenesis of Streptococcus pneumoniae-associated hemolytic uremic syndrome.Pediatric nephrology (Berlin, Germany) · 2020Review
- Article
- Impact of the pneumococcal 10-valent vaccine on reducing hospitalization for community-acquired pneumonia in children.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2016Article
- Pneumonia hospitalisations in Scotland following the introduction of pneumococcal conjugate vaccination in young children.BMC infectious diseases · 2016Article
- Using Standardized Interpretation of Chest Radiographs to Identify Adults with Bacterial Pneumonia--Guatemala, 2007-2012.PloS one · 2015Article
- A review of the role ofPneumonia (Nathan Qld.) · 2015Review
- Risk factors for a poor outcome among children admitted with clinically severe pneumonia to a university hospital in Rabat, Morocco.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2014Article
- Management of streptococcal pneumoniae-induced hemolytic uremic syndrome: a case report.Clinical nephrology. Case studies · 2014Article
- Assessment of health benefits and cost-effectiveness of 10-valent and 13-valent pneumococcal conjugate vaccination in Kenyan children.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial pneumonia is a substantial cause of childhood morbidity and mortality worldwide, but determination of pathogen-specific burden remains a challenge. In less developed settings, the WHO recommended guidelines are useful for initiating care, but are non-specific. Blood culture has low sensitivity, while radiological findings are non-specific and do not discriminate between viral and bacterial causes of pneumonia. In vaccine probe studies, efficacy is dependent on the specificity of the study outcome to detect pneumonia and the impact of the vaccine on the selected outcome, and may underestimate the true burden of bacterial pneumonia. The rising incidence of antibiotic resistance, emerging respiratory pathogens, potential replacement pneumococcal disease following widespread introduction of pneumococcal polysaccharide-protein conjugate vaccine, the limited specificity of chest radiography, and the poor sensitivity of blood culture are substantial obstacles to accurate surveillance. We provide an overview of the diagnostic challenges of bacterial pneumonia and highlight the need for refining the current diagnostic approach to ensure adequate epidemiological surveillance of childhood pneumonia and the success, or otherwise, of any immunisation strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.