Evidence map›Paper›PMID 16498449›Full record

ReviewNature reviews. Immunology2006

CATERPILLERs, pyrin and hereditary immunological disorders.

Jenny P-Y Ting, Daniel L Kastner, Hal M Hoffman

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

137 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Associations ofArhiv za higijenu rada i toksikologiju · 2021
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
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  14. Oral Mucosal Epithelial Cells.Frontiers in immunology · 2019
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jenny P-Y TingDepartment of Microbiology-Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina 27599, USA. panyun@med.unc.edu
Daniel L Kastner
Hal M Hoffman

Funding

Genetics Of Familial Mediterranean Fever/ Related ConditZ01AR041083 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KASTNER, DANIEL L · 1990 to 2008
$3.3M
Genetics Of Familial Mediterranean Fever and Related ConditionsZIAAR041083 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI KASTNER, DANIEL · 2009 to 2010
$2.4M
6 · The paper itself

Abstract

The newly described CATERPILLER family (also known as NOD-LRR or NACHT-LRR) is comprised of proteins with a nucleotide-binding domain and a leucine-rich region. This family has gained rapid prominence because of its demonstrated and anticipated roles in immunity, cell death and growth, and diseases. CATERPILLER proteins are structurally similar to a subgroup of plant-disease-resistance (R) proteins and to the apoptotic protease activating factor 1 (APAF1). They provide positive and negative signals for the control of immune and inflammatory responses, and might represent intracellular sensors of pathogen products. Most importantly, they are genetically linked to several human immunological disorders.

Indexed as

Carrier ProteinsFamilial Mediterranean FeverGenes, MHC Class IIHumansImmune System DiseasesInterleukin-1Intracellular Signaling Peptides and ProteinsMutationNeuronal Apoptosis-Inhibitory ProteinNLR Family, Pyrin Domain-Containing 3 ProteinNod2 Signaling Adaptor ProteinNuclear ProteinsTrans-ActivatorsCarrier ProteinsInterleukin-1Intracellular Signaling Peptides and ProteinsMHC class II transactivator proteinNAIP protein, humanNeuronal Apoptosis-Inhibitory ProteinNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanNOD2 protein, humanNod2 Signaling Adaptor ProteinNuclear ProteinsTrans-Activators

Identifiers

PMID16498449

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.