Trial reportEmergency medicine journal : EMJ2006
Is atropine needed with ketamine sedation? A prospective, randomised, double blind study.
Trial report in Emergency medicine journal : EMJ, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 113 citations in OpenAlex.
- Anticholinergic premedication-induced fever in paediatric ambulatory ketamine anaesthesia.The Journal of international medical research · 2016Trial
- Ketamine alone versus combination regimens for sedation in pediatric trauma in emergency care: a network meta-analysis.European journal of pediatrics · 2026Article
- Midazolam-Ketamine (MK) Versus Propofol-Ketamine (PK) for Pediatric Burn Patients Undergoing Dressing Changes: A Non-Randomized Cross-Over Clinical Trial.Annals of burns and fire disasters · 2025Article
- The diverse effects of ketamine, jack-of-all-trades: a narrative review.British journal of anaesthesia · 2025Review
- Analgosedation in Pediatric Emergency Care: A Comprehensive Scoping Review.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Study on the mechanism of Gastrodiae Rhizoma, Lycii Fructus, and Ziziphi Spinosae Semen in sedation and tranquillising mind.Molecular diversity · 2024Article
- Review
- Use of Early Ketamine Sedation and Association With Clinical and Cost Outcomes Among Mechanically Ventilated Patients With COVID-19: A Retrospective Cohort Study.Critical care explorations · 2024Article
- Efficacy and safety of ketamine in mechanically ventilated intensive care unit patients: a scoping review.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2022Article
- Factors affecting airway compliance and resistance in children receiving general anesthesia during adenotonsillectomy.Medicine · 2020Observational
- Article
- A comparison of sedation with midazolam-ketamine versus propofol-fentanyl during endoscopy in children: a randomized trial.European journal of gastroenterology & hepatology · 2017Article
- Ketamine Sedation in Gastrointestinal Endoscopy in Children.Open access Macedonian journal of medical sciences · 2016Article
- Review on sedation for gastrointestinal tract endoscopy in children by non-anesthesiologists.World journal of gastrointestinal endoscopy · 2015Article
- The design of a multicentre Canadian surveillance study of sedation safety in the paediatric emergency department.BMJ open · 2015Article
- A comparison of ketamine-midazolam and ketamine-propofol combinations used for sedation in the endobronchial ultrasound-guided transbronchial needle aspiration: a prospective, single-blind, randomized study.Journal of thoracic disease · 2014Article
- Sedation of children for auditory brainstem response using ketamine-midazolam-atropine combination - a retrospective analysis.SpringerPlus · 2013Article
- Sedoanalgesia in pediatric daily surgery.International journal of clinical and experimental medicine · 2013Article
- Ketamine and midazolam sedation for pediatric gastrointestinal endoscopy in the Arab world.World journal of gastroenterology · 2011Article
- Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies.The Lancet. Neurology · 2008Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare atropine with placebo as an adjunct to ketamine sedation in children undergoing minor painful procedures. Outcome measures included hypersalivation, side effect profile, parental/patient satisfaction, and procedural success rate.
methodsChildren aged between 1 and 16 years of age requiring ketamine procedural sedation in a tertiary emergency department were randomised to receive 0.01 mg/kg of atropine or placebo. All received 4 mg/kg of intramuscular ketamine. Tolerance and sedation scores were recorded throughout the procedure. Side effects were recorded from the start of sedation until discharge. Parental and patient satisfaction scores were obtained at discharge and three to five days after the procedure, with the opportunity to report side effects encountered at home.
resultsA total of 83 patients aged 13 months to 14.5 years (median age 3.4 years) were enrolled over a 16 month period. Hypersalivation occurred in 11.4% of patients given atropine compared with 30.8% given placebo (odds ratio (OR) 0.29, 95% confidence interval (CI) 0.09 to 0.91). A transient rash was observed in 22.7% of the atropine group compared with 5.1% of the placebo group (OR 5.44, 95% CI 1.11 to 26.6). Vomiting during recovery occurred in 9.1% of atropine patients compared with 25.6% of placebo patients (OR 0.29, 95% CI 0.09 to 1.02). There was a trend towards better tolerance in the placebo group. No patient experienced serious side effects.
conclusionKetamine sedation was successful and well tolerated in all cases. The use of atropine as an adjunct for intramuscular ketamine sedation in children significantly reduces hypersalivation and may lower the incidence of post-procedural vomiting. Atropine is associated with a higher incidence of a transient rash. No serious adverse events were noted.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.