ArticleAmerican journal of respiratory cell and molecular biology2006
Human lung project: evaluating variance of gene expression in the human lung.
Article in American journal of respiratory cell and molecular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Gene expression in tumor and adjacent normal tissues in lung adenocarcinoma subtypes.BMC cancer · 2025Article
- GateView: A Multi-Omics Platform for Gene Feature Analysis of Virus Receptors within Human Normal Tissues and Tumors.Biomolecules · 2024Article
- Review
- Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract.Developmental cell · 2020Article
- Gene Expression: the Key to Understanding HIV-1 Infection?Microbiology and molecular biology reviews : MMBR · 2020Review
- Lung transcriptomic clock predicts premature aging in cigarette smoke-exposed mice.BMC genomics · 2020Article
- NKX2-1-AS1 negatively regulates CD274/PD-L1, cell-cell interaction genes, and limits human lung carcinoma cell migration.Scientific reports · 2018Article
- Unique Immune Gene Expression Patterns in Bronchoalveolar Lavage and Tumor Adjacent Non-Neoplastic Lung Tissue in Non-Small Cell Lung Cancer.Frontiers in immunology · 2018Article
- The Intersection of Aging Biology and the Pathobiology of Lung Diseases: A Joint NHLBI/NIA Workshop.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Review
- Human Lung Tissue Transcriptome: Influence of Sex and Age.PloS one · 2016Article
- Prediction of Clinical Outcome for All Stages and Multiple Cell Types of Non-small Cell Lung Cancer in Five Countries Using Lung Cancer Prognostic Index.EBioMedicine · 2014Article
- Alterations in gene expression of proprotein convertases in human lung cancer have a limited number of scenarios.PloS one · 2013Article
- High correlation of the response of upper and lower lobe small airway epithelium to smoking.PloS one · 2013Article
- Article
- Association of smoking with tumor size at diagnosis in non-small cell lung cancer.Lung cancer (Amsterdam, Netherlands) · 2011Article
- Microarray analysis of sexually dimorphic gene expression in human minor salivary glands.Oral diseases · 2011Article
- Smoking reduces surfactant protein D and phospholipids in patients with and without chronic obstructive pulmonary disease.BMC pulmonary medicine · 2010Article
- Regulated gene expression in cultured type II cells of adult human lung.American journal of physiology. Lung cellular and molecular physiology · 2010Article
- Article
- Secretory leukocyte peptidase inhibitor and lung cancer.Cancer science · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Nondiseased tissue is an important reference for microarray studies of pulmonary disease. We obtained 23 single lungs from multiorgan donors at time of procurement. Donors varied in age, sex, smoking history, and ethnicity. Lungs were dissected into upper and lower lobe peripheral sections for RNA extraction. Microarray analysis was performed using Affymetrix Hu-133 Plus 2.0 arrays. We observed that the relative variability of gene expression increased rapidly from technical (lowest), to regional, to population (highest). In addition, age and sex have measurable effects on gene expression. Gene expression variability is heterogeneously distributed among biologic categories. We conclude that gene expression variability is greater between individuals than within individuals and that population variability is the most important factor in the study design of microarray experiments of the human lung. Classes of genes with high population variability are biologically important and provide a novel perspective into lung physiology and pathobiology. Our study represents the first comprehensive analysis of nondiseased lung tissue. The generation of this robust dataset has important implications for the design and implementation of future comparative expression analysis with pulmonary disease states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.