ArticleThe Journal of physiology2006
Alveolar type I cells protect rat lung epithelium from oxidative injury.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology.Molecular psychiatry · 2021Review
- Comparison of Local and Systemic DTPA Treatment Efficacy According to Actinide Physicochemical Properties Following Lung or Wound Contamination in the Rat.Frontiers in pharmacology · 2021Article
- More Than Just a Barrier: The Immune Functions of the Airway Epithelium in Asthma Pathogenesis.Frontiers in immunology · 2020Review
- Plasma proteomics reveals gestational age-specific responses to mechanical ventilation and identifies the mechanistic pathways that initiate preterm lung injury.Scientific reports · 2018Article
- The APOE ε4 allele is associated with a reduction in FEV1/FVC in women: A cross-sectional analysis of the Long Life Family Study.PloS one · 2018Article
- High Nrf2 expression in alveolar type I pneumocytes is associated with low recurrences in primary spontaneous pneumothorax.The Kaohsiung journal of medical sciences · 2017Article
- A Critical Role for P2X7 Receptor-Induced VCAM-1 Shedding and Neutrophil Infiltration during Acute Lung Injury.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Emerging Roles of Apolipoprotein E and Apolipoprotein A-I in the Pathogenesis and Treatment of Lung Disease.American journal of respiratory cell and molecular biology · 2016Review
- Wnt3a mitigates acute lung injury by reducing P2X7 receptor-mediated alveolar epithelial type I cell death.Cell death & disease · 2014Article
- miR-375 regulates rat alveolar epithelial cell trans-differentiation by inhibiting Wnt/β-catenin pathway.Nucleic acids research · 2013Article
- GABA receptor ameliorates ventilator-induced lung injury in rats by improving alveolar fluid clearance.Critical care (London, England) · 2012Article
- Regulation of lung surfactant secretion by microRNA-150.Biochemical and biophysical research communications · 2012Article
- Apolipoprotein mimetic peptides: a new approach for the treatment of asthma.Frontiers in pharmacology · 2012Article
- Major shifts in the spatio-temporal distribution of lung antioxidant enzymes during influenza pneumonia.PloS one · 2012Article
- Age-related differences in cigarette smoke extract-induced H2O2 production by lung endothelial cells.Microvascular research · 2011Article
- Purinergic P2X7 receptor regulates lung surfactant secretion in a paracrine manner.Journal of cell science · 2011Article
- Directed expression of Cre in alveolar epithelial type 1 cells.American journal of respiratory cell and molecular biology · 2010Article
- Regulated gene expression in cultured type II cells of adult human lung.American journal of physiology. Lung cellular and molecular physiology · 2010Article
- MCP-1 antibody treatment enhances damage and impedes repair of the alveolar epithelium in influenza pneumonitis.American journal of respiratory cell and molecular biology · 2010Article
- Regulatory T cell-mediated resolution of lung injury: identification of potential target genes via expression profiling.Physiological genomics · 2010Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The lung alveolar surface is covered by two morphologically and functionally distinct cells: alveolar epithelial cell types I and II (AEC I and II). The functions of AEC II, including surfactant release, cell differentiation and ion transport, have been extensively studied. However, relatively little is known regarding the physiological functions of AEC I. Global gene expression profiling of freshly isolated AEC I and II revealed that many genes were differentially expressed in AEC I. These genes have a diversity of functions, including cell defence. Nine out of 10 selected genes were verified by quantitative real-time PCR. Two genes, apolipoprotein E (Apo E) and transferrin, were further characterized and functionally studied. Immunohistochemistry indicated that both proteins were specifically localized in AEC I. Up-regulation of Apo E and transferrin was observed in hyperoxic lungs. Functionally, Apo E and transferrin play a protective role against oxidative stress in an animal model. Our studies suggest that AEC I is not just a simple barrier for gas exchange, but a functional cell that protects alveolar epithelium from injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.