ArticleThe Journal of physiology2006
Modulation of Ca(2+)-activated K+ currents and Ca(2+)-dependent action potentials by exocytosis in goldfish bipolar cell terminals.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 26 citations in OpenAlex.
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
- Molecular and Cellular Mechanisms Underlying Somatostatin-Based Signaling in Two Model Neural Networks, the Retina and the Hippocampus.International journal of molecular sciences · 2019Review
- Direct measurement of bipolar cell responses to electrical stimulation in wholemount mouse retina.Journal of neural engineering · 2018Article
- Method to remove photoreceptors from whole mount retina in vitro.Journal of neurophysiology · 2017Article
- Calcium-activated BKThe Journal of physiology · 2017Article
- Calcium spike-mediated digital signaling increases glutamate output at the visual threshold of retinal bipolar cells.Journal of neurophysiology · 2015Article
- Origins of spontaneous activity in the degenerating retina.Frontiers in cellular neuroscience · 2015Review
- Nitric oxide mediates activity-dependent plasticity of retinal bipolar cell output via S-nitrosylation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Spikes in retinal bipolar cells phase-lock to visual stimuli with millisecond precision.Current biology : CB · 2011Article
- In vivo evidence that retinal bipolar cells generate spikes modulated by light.Nature neuroscience · 2011Article
- An intrinsic neural oscillator in the degenerating mouse retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Synaptic release at mammalian bipolar cell terminals.Visual neuroscience · 2011Review
- Active roles of electrically coupled bipolar cell network in the adult retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Differential effects of charybdotoxin on the activity of retinal ganglion cells in the dark- and light-adapted mouse retina.Vision research · 2009Article
- GABA transporters regulate a standing GABAC receptor-mediated current at a retinal presynaptic terminal.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
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Abstract
Retinal bipolar cells convey light-evoked potentials from photoreceptors to ganglion cells and mediate the initial stages of visual signal processing. They do not fire Na(+)-dependent action potentials (APs) but the Mb1 class of goldfish bipolar cell exhibits Ca(2+)-dependent APs and regenerative potentials that originate in the axon terminal. I have examined the properties of Ca(2+)-dependent APs in isolated bipolar-cell terminals in goldfish retinal slices. All recorded terminals fired spontaneous or evoked APs at frequencies of up to 15 Hz. When an AP waveform was used as a voltage stimulus, exocytosis was evoked by single APs, maintained throughout AP trains and modulated by AP frequency. Furthermore, feedback inhibition of the Ca2+ current (I(Ca)) by released vesicular protons reduced depression of exocytosis during AP trains. In the absence of K+ current inhibition, step depolarizations and AP waveforms evoked a rapidly activated outward current that was dependent on Ca2+ influx I(K(Ca). I therefore investigated whether proton-mediated feedback inhibition of I(Ca) affected the activation of I(K(Ca)). A transient inhibition of I(K(Ca)) was observed that was dependent on exocytosis, blocked by high-pH extracellular buffer, of similar magnitude to inhibition of I(Ca) but occurred with a delay of 2.7 ms. In addition, the amplitude of APs evoked under current clamp was inhibited by the action of vesicular protons released by the APs. Protons released via exocytosis may therefore be a significant modulator of Ca(2+)-dependent currents and regenerative potentials in bipolar-cell terminals.
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