ArticleInfection and immunity2006
Screening for Toxoplasma gondii-regulated transcriptional responses in lipopolysaccharide-activated macrophages.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Early upregulation of immune suppressors dominates the macrophage response to Toxoplasma gondii.PloS one · 2025Article
- Microbiota promotes recruitment and pro-inflammatory response of caecal macrophages during E. tenella infection.Gut pathogens · 2023Article
- Toxoplasma gondii Manipulates Expression of Host Long Noncoding RNA during Intracellular Infection.Scientific reports · 2018Article
- Inflammatory molecular signature associated with infectious agents in psychosis.Schizophrenia bulletin · 2014Article
- An inside job: hacking into Janus kinase/signal transducer and activator of transcription signaling cascades by the intracellular protozoan Toxoplasma gondii.Infection and immunity · 2012Review
- Synergy between intraepithelial lymphocytes and lamina propria T cells drives intestinal inflammation during infection.Mucosal immunology · 2011Article
- Dysregulation of macrophage signal transduction by Toxoplasma gondii: past progress and recent advances.Parasite immunology · 2009Review
- Toxoplasma gondii inhibits covalent modification of histone H3 at the IL-10 promoter in infected macrophages.PloS one · 2009Article
- Host cell transcriptional profiling during malaria liver stage infection reveals a coordinated and sequential set of biological events.BMC genomics · 2009Article
- Functional aspects of Toll-like receptor/MyD88 signalling during protozoan infection: focus on Toxoplasma gondii.Clinical and experimental immunology · 2009Review
- Toxoplasma gondii prevents chromatin remodeling initiated by TLR-triggered macrophage activation.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Suppressed production of pro-inflammatory cytokines by LPS-activated macrophages after treatment with Toxoplasma gondii lysate.The Korean journal of parasitology · 2008Article
- Phosphoinositide-3-kinase-dependent, MyD88-independent induction of CC-type chemokines characterizes the macrophage response to Toxoplasma gondii strains with high virulence.Infection and immunity · 2007Article
- Infection with Toxoplasma gondii bradyzoites has a diminished impact on host transcript levels relative to tachyzoite infection.Infection and immunity · 2007Article
Corrections and comments
- Commented on by
Authors and funding
3 authors.
Funding
Abstract
Toxoplasma gondii-infected macrophages are blocked in production of the proinflammatory cytokines interleukin-12 (IL-12) and tumor necrosis factor alpha (TNF-alpha) upon activation with lipopolysaccharide (LPS). Here, we used pathway-focused cDNA arrays to identify additional T. gondii-regulated transcriptional responses. Parasite infection decreased 57 (inclusive of IL-12 and TNF-alpha) and increased expression of 7 of 77 LPS-activated cytokine and cytokine-related genes. Interestingly, we found that the LPS-induced transcriptional response of the anti-inflammatory cytokine IL-10 was synergistically increased by T. gondii, results that we validated by conventional reverse transcription-PCR and enzyme-linked immunosorbent assay. Importantly, although the parasite exerted disparate effects in LPS-signaling leading to TNF-alpha versus IL-10 production, both responses required functional Toll-like receptor 4. We suggest that these effects represent parasite defense mechanisms to avoid or delay induction of antimicrobial activity and/or T-cell-mediated immunity during Toxoplasma infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.