ArticleInfection and immunity2006
Silencing of the laminin gamma-1 gene blocks Trypanosoma cruzi infection.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Reprogramming of Trypanosoma cruzi metabolism triggered by parasite interaction with the host cell extracellular matrix.PLoS neglected tropical diseases · 2019Article
- Congenital Transmission ofFrontiers in microbiology · 2019Review
- Mechanisms of Infectivity and Evasion Derived from Microvesicles Cargo Produced byFrontiers in cellular and infection microbiology · 2016Review
- Immunization with Hexon modified adenoviral vectors integrated with gp83 epitope provides protection against Trypanosoma cruzi infection.PLoS neglected tropical diseases · 2014Article
- Fibronectin modulates thymocyte-thymic epithelial cell interactions following Trypanosoma cruzi infection.Memorias do Instituto Oswaldo Cruz · 2013Article
- Cellular response to Trypanosoma cruzi infection induces secretion of defensin α-1, which damages the flagellum, neutralizes trypanosome motility, and inhibits infection.Infection and immunity · 2013Article
- MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells.The Journal of biological chemistry · 2013Article
- VNI cures acute and chronic experimental Chagas disease.The Journal of infectious diseases · 2013Article
- siRNA Genome Screening Approaches to Therapeutic Drug Repositioning.Pharmaceuticals (Basel, Switzerland) · 2013Article
- Host-parasite interaction: parasite-derived and -induced proteases that degrade human extracellular matrix.Journal of parasitology research · 2012Article
- Thrombospondin-1 interacts with Trypanosoma cruzi surface calreticulin to enhance cellular infection.PloS one · 2012Article
- Article
- Design of potential siRNA molecules for hepatitis delta virus gene silencing.Bioinformation · 2012Article
- Regulation and use of the extracellular matrix by Trypanosoma cruzi during early infection.Frontiers in immunology · 2012Article
- Reorganization of extracellular matrix in placentas from women with asymptomatic chagas disease: mechanism of parasite invasion or local placental defense?Journal of tropical medicine · 2012Article
- Visual genome-wide RNAi screening to identify human host factors required for Trypanosoma cruzi infection.PloS one · 2011Article
- Gene network analysis during early infection of human coronary artery smooth muscle cells by Trypanosoma cruzi and Its gp83 ligand.Chemistry & biodiversity · 2010Article
- REGULATION of the EXTRACELLULAR MATRIX INTERACTOME by Trypanosoma cruzi.The open parasitology journal · 2010Article
- Perspectives on the Trypanosoma cruzi-host cell receptor interactions.Parasitology research · 2009Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
It is thought that Trypanosoma cruzi, the protozoan that causes Chagas' disease, modulates the extracellular matrix network to facilitate infection of human cells. However, direct evidence to document this phenomenon is lacking. Here we show that the T. cruzi gp83 ligand, a cell surface trans-sialidase-like molecule that the parasite uses to attach to host cells, increases the level of laminin gamma-1 transcript and its expression in mammalian cells, leading to an increase in cellular infection. Stable RNA interference (RNAi) with host cell laminin gamma-1 knocks down the levels of laminin gamma-1 transcript and protein expression in mammalian cells, causing a dramatic reduction in cellular infection by T. cruzi. Thus, host laminin gamma-1, which is regulated by the parasite, plays a crucial role in the early process of infection. This is the first report showing that knocking down the expression of a human gene by RNAi inhibits the infection of an intracellular parasite.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.