ArticleInfection and immunity2006
CD40 restrains in vivo growth of Toxoplasma gondii independently of gamma interferon.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
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- Influence of the Host and Parasite Strain on the Immune Response DuringFrontiers in cellular and infection microbiology · 2020Review
- The role of host autophagy machinery in controllingVirulence · 2019Review
- The Interplay of Host Autophagy and Eukaryotic Pathogens.Frontiers in cell and developmental biology · 2018Review
- STAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System.mBio · 2016Article
- The morphological analysis of autophagy in primary skeletal muscle cells infected with Toxoplasma gondii.Parasitology research · 2016Article
- The Evolving Functions of Autophagy in Ocular Health: A Double-edged Sword.International journal of biological sciences · 2016Review
- Type II Toxoplasma gondii induction of CD40 on infected macrophages enhances interleukin-12 responses.Infection and immunity · 2014Article
- Immune response and immunopathology during toxoplasmosis.Seminars in immunopathology · 2012Review
- Article
- Neutralization of malaria glycosylphosphatidylinositol in vitro by serum IgG from malaria-exposed individuals.Infection and immunity · 2010Article
- CD40 and the immune response to parasitic infections.Seminars in immunology · 2009Review
- Autophagy as an antimicrobial strategy.Expert review of anti-infective therapy · 2009Review
- Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens.Cell host & microbe · 2008Article
- Rapid elimination of Toxoplasma gondii by gamma interferon-primed mouse macrophages is independent of CD40 signaling.Infection and immunity · 2007Article
- CD40-CD40L interaction in immunity against protozoan infections.Journal of biomedicine & biotechnology · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
CD40-CD154 interaction is pivotal for resistance against numerous pathogens. However, it is not known if this pathway can also enhance in vivo resistance in gamma interferon (IFN-gamma)-deficient hosts. This is an important question because patients and mice with defects in type 1 cytokine response can control a variety of pathogens. While blockade of endogenous CD154 resulted in a remarkable increase in parasite load in IFN-gamma-/- mice infected with Toxoplasma gondii, in vivo administration of a stimulatory anti-CD40 monoclonal antibody markedly reduced parasite load. This latter effect took place even in T-cell-depleted mice and was accompanied by induction of macrophage toxoplasmacidal activity. CD40 stimulation restricted T. gondii replication independently of STAT1, p47 GTPases, and nitric oxide. In vivo CD40 ligation enhanced tumor necrosis factor alpha (TNF-alpha) production by T. gondii-infected macrophages. In addition, CD40 stimulation required the presence of TNF receptor 2 to reduce parasite load in vivo. These results suggest that CD40-CD154 interaction regulates IFN-gamma-independent mechanisms of host protection through induction of macrophage antimicrobial activity and modulation of TNF-alpha signaling.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.