ArticleInfection and immunity2006
The proinflammatory response induced by wild-type Yersinia pseudotuberculosis infection inhibits survival of yop mutants in the gastrointestinal tract and Peyer's patches.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- γδ T cell IFNγ production is directly subverted by Yersinia pseudotuberculosis outer protein YopJ in mice and humans.PLoS pathogens · 2021Article
- Spatiotemporal Variations in Growth Rate and Virulence Plasmid Copy Number duringInfection and immunity · 2021Article
- Yersinia pseudotuberculosis YopH targets SKAP2-dependent and independent signaling pathways to block neutrophil antimicrobial mechanisms during infection.PLoS pathogens · 2020Article
- Unraveling neutrophil-F1000Research · 2019Review
- CCR2Infection and immunity · 2018Article
- AllFrontiers in cellular and infection microbiology · 2018Review
- Clinical efficacy of short-course chemotherapy combined with topical injection therapy in treatment of superficial lymph node tuberculosis.Oncotarget · 2017Article
- Yersinia enterocolitica YopH-Deficient Strain Activates Neutrophil Recruitment to Peyer's Patches and Promotes Clearance of the Virulent Strain.Infection and immunity · 2016Article
- Lipopolysaccharide Biosynthesis Genes of Yersinia pseudotuberculosis Promote Resistance to Antimicrobial Chemokines.PloS one · 2016Article
- Bone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection.Immunity · 2015Article
- Natural Killer Cells Mediate Protection against Yersinia pseudotuberculosis in the Mesenteric Lymph Nodes.PloS one · 2015Article
- Salmonella acquires ferrous iron from haemophagocytic macrophages.Molecular microbiology · 2014Article
- Yersinia pseudotuberculosis efficiently escapes polymorphonuclear neutrophils during early infection.Infection and immunity · 2014Article
- The route less taken: pulmonary models of enteric Gram-negative infection.Pathogens and disease · 2014Review
- Adhesins and host serum factors drive Yop translocation by yersinia into professional phagocytes during animal infection.PLoS pathogens · 2013Article
- Role of YopK in Yersinia pseudotuberculosis resistance against polymorphonuclear leukocyte defense.Infection and immunity · 2013Article
- ROS-inhibitory activity of YopE is required for full virulence of Yersinia in mice.Cellular microbiology · 2010Article
- YopH inhibits early pro-inflammatory cytokine responses during plague pneumonia.BMC immunology · 2010Article
- YopJ-promoted cytotoxicity and systemic colonization are associated with high levels of murine interleukin-18, gamma interferon, and neutrophils in a live vaccine model of Yersinia pseudotuberculosis infection.Infection and immunity · 2010Article
- The Yersinia pestis Ail protein mediates binding and Yop delivery to host cells required for plague virulence.Infection and immunity · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Single-strain infections and coinfections are frequently used to assess roles of virulence factors in infected tissues. After oral inoculation of mice, Yersinia pseudotuberculosis yopE and yopH mutants colonize the intestines and Peyer's patches in single-strain infections but fail to persist in competition with wild-type Y. pseudotuberculosis, indicating that these two infection models provide different insights into the roles of Yops. To determine how wild-type Y. pseudotuberculosis hinders yop mutant survival, yop mutant colonization and host responses were investigated in several different infection models that isolated specific features of wild-type Y. pseudotuberculosis infection. Infection with wild-type Y. pseudotuberculosis caused significantly more inflammation than yop mutants. Results from coinfections of gamma interferon (IFN-gamma)-/- mice revealed that IFN-gamma-regulated defenses target these mutants, suggesting that YopE and YopH protect Y. pseudotuberculosis from these defenses in BALB/c mice. We developed an oral-intraperitoneal infection model to evaluate the effects of spleen and liver colonization by Y. pseudotuberculosis on yop mutants in the intestines. Spleen and liver infection increased inflammation and decreased yop mutant survival in the intestines, indicating that infection of these organs has consequences in intestinal tissues. Finally, competition infections with Y. pseudotuberculosis mutants with various abilities to induce inflammation demonstrated that survival of the yopE, but not the yopH, mutant was consistently decreased in inflamed tissues. In summary, infection with Y. pseudotuberculosis in intestinal and systemic sites induces intestinal inflammation, which decreases yop mutant survival. Thus, competition studies with wild-type yersiniae reveal critical roles of Yops in combating host responses to a normal virulent infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.