ArticleInfection and immunity2006
Mutual enhancement of virulence by enterotoxigenic and enteropathogenic Escherichia coli.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Attaching and effacing pathogens modulate host mitochondrial structure and function.International review of cell and molecular biology · 2023Review
- A One Health Perspective for Defining and DecipheringComparative medicine · 2021Review
- Enterotoxigenic Escherichia coli heat labile enterotoxin inhibits intestinal ascorbic acid uptake via a cAMP-dependent NF-κB-mediated pathway.American journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Trypanosoma cruzi Differentiates and Multiplies within Chimeric Parasitophorous Vacuoles in Macrophages Coinfected with Leishmania amazonensis.Infection and immunity · 2016Article
- Exposure to pairs of Aeromonas strains enhances virulence in the Caenorhabditis elegans infection model.Frontiers in microbiology · 2015Article
- Enterotoxigenic Escherichia coli infection and intestinal thiamin uptake: studies with intestinal epithelial Caco-2 monolayers.American journal of physiology. Cell physiology · 2013Article
- Role of host xanthine oxidase in infection due to enteropathogenic and Shiga-toxigenic Escherichia coli.Infection and immunity · 2013Article
- A DNA pooling based system to detect Escherichia coli virulence factors in fecal and wastewater samples.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2012Article
- Analysis of global transcriptional profiles of enterotoxigenic Escherichia coli isolate E24377A.Infection and immunity · 2012Article
- Plesiomonas shigelloides infection, Ecuador, 2004-2008.Emerging infectious diseases · 2012Article
- Virulence inhibition by zinc in shiga-toxigenic Escherichia coli.Infection and immunity · 2011Article
- Concomitant enterotoxigenic Escherichia coli infection induces increased immune responses to Vibrio cholerae O1 antigens in patients with cholera in Bangladesh.Infection and immunity · 2010Article
- Feedback effects of host-derived adenosine on enteropathogenic Escherichia coli.FEMS immunology and medical microbiology · 2009Article
- Toxin-mediated effects on the innate mucosal defenses: implications for enteric vaccines.Infection and immunity · 2009Review
- Thiophenecarboxylate suppressor of cyclic nucleotides discovered in a small-molecule screen blocks toxin-induced intestinal fluid secretion.Molecular pharmacology · 2009Article
- Heat-labile enterotoxin promotes Escherichia coli adherence to intestinal epithelial cells.Journal of bacteriology · 2009Article
- Effect of zinc in enteropathogenic Escherichia coli infection.Infection and immunity · 2007Article
- Ecto-5'-nucleotidase and intestinal ion secretion by enteropathogenic Escherichia coli.Purinergic signalling · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Enterotoxigenic Escherichia coli (ETEC) and enteropathogenic E. coli (EPEC) are common causes of diarrhea in children in developing countries. Dual infections with both pathogens have been noted fairly frequently in studies of diarrhea around the world. In previous laboratory work, we noted that cholera toxin and forskolin markedly potentiated EPEC-induced ATP release from the host cell, and this potentiated release was found to be mediated by the cystic fibrosis transmembrane conductance regulator. In this study, we examined whether the ETEC heat-labile toxin (LT) or the heat-stable toxin (STa, also known as ST) potentiated EPEC-induced ATP release. We found that crude ETEC culture filtrates, as well as purified ETEC toxins, did potentiate EPEC-induced ATP release in cultured T84 cells. Coinfection of T84 cells with live ETEC plus EPEC bacteria also resulted in enhanced ATP release compared to EPEC alone. In Ussing chamber studies of chloride secretion, adenine nucleotides released from the host by EPEC also significantly enhanced the chloride secretory responses that were triggered by crude ETEC filtrates, purified STa, and the peptide hormone guanylin. In addition, adenosine and LT had additive or synergistic effects in inducing vacuole formation in T84 cells. Therefore, ETEC toxins and EPEC-induced damage to the host cell both enhance the virulence of the other type of E. coli. Our in vitro data demonstrate a molecular basis for a microbial interaction, which could result in increased severity of disease in vivo in individuals who are coinfected with ETEC and EPEC.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.