ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Synaptic bombardment modulates muscarinic effects in forelimb motor cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 35 citations in OpenAlex.
- Focusing effect of acetylcholine on neuroplasticity in the human motor cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Trial
- Muscarinic and Nicotinic Modulation of Neocortical Layer 6A Synaptic Microcircuits Is Cooperative and Cell-Specific.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Activity Clamp Provides Insights into Paradoxical Effects of the Anti-Seizure Drug Carbamazepine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Monoaminergic Modulation of Motor Cortex Function.Frontiers in neural circuits · 2017Review
- MATLAB-based automated patch-clamp system for awake behaving mice.Journal of neurophysiology · 2015Article
- Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability.Frontiers in behavioral neuroscience · 2015Article
- Correlation of cognitive performance and morphological changes in neocortical pyramidal neurons in aging.Neurobiology of aging · 2012Article
- Article
- Synaptic and intrinsic balancing during postnatal development in rat pups exposed to valproic acid in utero.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Dynamic clamp with StdpC software.Nature protocols · 2011Article
- Pyramidal neuron conductance state gates spike-timing-dependent plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- The homeobox transcription factor Barx2 regulates plasticity of young primary myofibers.PloS one · 2010Article
- Cholinergic filtering in the recurrent excitatory microcircuit of cortical layer 4.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Dopamine neuron responses depend exponentially on pacemaker interval.Journal of neurophysiology · 2009Article
- The cortical energy needed for conscious perception.NeuroImage · 2008Article
- The regulation of M1 muscarinic acetylcholine receptor desensitization by synaptic activity in cultured hippocampal neurons.Journal of neurochemistry · 2007Article
- Reactive oxygen species modulate the differentiation of neurons in clonal cortical cultures.Molecular and cellular neurosciences · 2006Article
- Article
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2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Neocortical neurons in vivo exist in an environment of continuous synaptic bombardment, receiving a complex barrage of excitatory and inhibitory inputs. This background activity (by depolarizing neurons, increasing membrane conductance, and introducing fluctuations) strongly alters many aspects of neuronal responsiveness. In this study, we asked how it shapes neuromodulation of postsynaptic responses. Specifically, we examined muscarinic modulation of forelimb motor cortex, a brain area in which cholinergic stimulation is known to be necessary for modifications during motor skill learning. Using a dynamic clamp system to inject simulated conductances into pyramidal neurons in motor cortical slices, we mimicked in vivo-like activity by introducing a random background of excitatory and inhibitory inputs. When muscarinic receptors were stimulated with the agonist oxotremorine-M, several previously described currents were modified, and excitability was increased. However, the presence of the background conductances strongly attenuated most muscarinic agonist effects, with the notable exception that sustained firing responses to trains of inputs were well preserved. This may be important for promoting plasticity in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.