ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Synaptic vesicle recycling adapts to chronic changes in activity.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Dopaminergic tone inhibits spontaneous glutamate release and augments homeostatic synaptic plasticity.Molecular psychiatry · 2026Article
- Synaptic vesicle pool heterogeneity drives an anomalous form of synaptic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The cross-talk of energy sensing and mitochondrial anchoring sustains synaptic efficacy by maintaining presynaptic metabolism.Nature metabolism · 2020Article
- Review
- Dynamic Partitioning of Synaptic Vesicle Pools by the SNARE-Binding Protein Tomosyn.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Neuronal activity controls transsynaptic geometry.Scientific reports · 2016Article
- Fine-tuning of synaptic upscaling at excitatory synapses by endocannabinoid signaling is mediated via the CB1 receptor.Scientific reports · 2015Article
- Contributions of Bcl-xL to acute and long term changes in bioenergetics during neuronal plasticity.Biochimica et biophysica acta · 2014Review
- Elongation factor-2 phosphorylation in dendrites and the regulation of dendritic mRNA translation in neurons.Frontiers in cellular neuroscience · 2014Review
- Dynamin 1 is required for memory formation.PloS one · 2014Article
- A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis.Nature cell biology · 2013Article
- Analysis of synaptic vesicle endocytosis in synaptosomes by high-content screening.Nature protocols · 2012Article
- A study of clustered data and approaches to its analysis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Acute dynamin inhibition dissects synaptic vesicle recycling pathways that drive spontaneous and evoked neurotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Functional heterogeneity at dopamine release sites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Synaptic vesicle protein trafficking at the glutamate synapse.Neuroscience · 2009Review
- Activity-dependent suppression of miniature neurotransmission through the regulation of DNA methylation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Multiple vesicle recycling pathways in central synapses and their impact on neurotransmission.The Journal of physiology · 2007Review
- Fast synaptic vesicle reuse slows the rate of synaptic depression in the CA1 region of hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Synaptic vesicle recycling is essential for maintaining neurotransmission during rhythmic activity. To test whether the demands imposed by ambient activity influences synaptic vesicle trafficking, we compared the kinetics of synaptic depression in hippocampal versus neocortical cultures, which have high and low levels of intrinsic activity, respectively. In response to moderate 10 Hz stimulation, hippocampal synapses depressed less compared with neocortical synapses, although they reused vesicles more slowly. Therefore, during stimulation, hippocampal synapses used more vesicles from the reserve pool, whereas neocortical synapses relied on vesicle reuse. In hippocampal cultures, chronic block of network activity increased synaptic depression by decreasing the rate of vesicle mobilization, with little effect on the rate of vesicle reuse. In contrast, in neocortical cultures, an increase in the normally low network activity reduced synaptic depression by robustly increasing vesicle reuse with no effect on vesicle mobilization. These results suggest that synaptic vesicle trafficking and the resulting synaptic dynamics adapt to meet the changing demands on neurotransmitter release. Furthermore, during these functional modifications, synapses use alternate strategies to adjust to changes in activity.
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