ArticleJournal of neurophysiology2006
Serotonergic modulation of inspiratory hypoglossal motoneurons in decerebrate dogs.
Article in Journal of neurophysiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Impact of Serotonergic 5HTInternational journal of molecular sciences · 2024Article
- Selective Serotonin Reuptake Inhibitors and 5-HTNeuroscience · 2023Article
- Criteria for central respiratory chemoreceptors: experimental evidence supporting current candidate cell groups.Frontiers in physiology · 2023Review
- Article
- Activation of upper airway muscles during breathing and swallowing.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Review
- Serotonin neurons and central respiratory chemoreception: where are we now?Progress in brain research · 2014Review
- The impact of atypical antipsychotic use on obstructive sleep apnea: a pilot study and literature review.Sleep medicine · 2011Review
- The role of medullary serotonin (5-HT) neurons in respiratory control: contributions to eupneic ventilation, CO2 chemoreception, and thermoregulation.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Review
- Episodic spinal serotonin receptor activation elicits long-lasting phrenic motor facilitation by an NADPH oxidase-dependent mechanism.The Journal of physiology · 2009Article
- Medullary serotonin neurons and central CO2 chemoreception.Respiratory physiology & neurobiology · 2009Review
- Role of inhibitory neurotransmission in the control of canine hypoglossal motoneuron activity in vivo.Journal of neurophysiology · 2009Article
- Contributions of 5-HT neurons to respiratory control: neuromodulatory and trophic effects.Respiratory physiology & neurobiology · 2008Review
- Postnatal changes in the expression of serotonin 2A receptors in various brain stem nuclei of the rat.Journal of applied physiology (Bethesda, Md. : 1985) · 2008Article
- Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Age-related changes in the serotonin 2A receptor in the hypoglossal nucleus of male and female rats.Respiratory physiology & neurobiology · 2007Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Inspiratory hypoglossal motoneurons (IHMNs) maintain upper airway patency. However, this may be compromised during sleep and by sedatives, potent analgesics, and volatile anesthetics by either depression of excitatory or enhancement of inhibitory inputs. In vitro data suggest that serotonin (5-HT), through the 5-HT2A receptor subtype, plays a key role in controlling the excitability of IHMNs. We hypothesized that in vivo 5-HT modulates IHMNs activity through the 5-HT2A receptor subtype. To test this hypothesis, we used multibarrel micropipettes for extracellular single neuron recording and pressure picoejection of 5-HT or ketanserin, a selective 5-HT2A receptor subtype antagonist, onto single IHMNs in decerebrate, vagotomized, paralyzed, and mechanically ventilated dogs. Drug-induced changes in neuronal discharge frequency (F(n)) and neuronal discharge pattern were analyzed using cycle-triggered histograms. 5-HT increased the control peak F(n) to 256% and the time-averaged F(n) to 340%. 5-HT increased the gain of the discharge pattern by 61% and the offset by 34 Hz. Ketanserin reduced the control peak F(n) by 68%, the time-averaged F(n) by 80%, and the gain by 63%. These results confirm our hypothesis that in vivo 5-HT is a potent modulator of IHMN activity through the 5-HT2A receptor subtype. Application of exogenous 5-HT shows that this mechanism is not saturated during hypercapnic hyperoxia. The two different mechanisms, gain modulation and offset change, indicate that 5-HT affects the excitability as well as the excitation of IHMNs in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.