ArticleMolecular biology of the cell2006
FUS1 regulates the opening and expansion of fusion pores between mating yeast.
Article in Molecular biology of the cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Cell fusion after wounding requires plasma membrane damage and endocytosis.bioRxiv : the preprint server for biology · 2026Article
- Article
- Mate and fuse: how yeast cells do it.Open biology · 2013Review
- Flow cytometry-based purification of S. cerevisiae zygotes.Journal of visualized experiments : JoVE · 2012Article
- Article
- Prm1 targeting to contact sites enhances fusion during mating in Saccharomyces cerevisiae.Eukaryotic cell · 2010Article
- Prm1 functions as a disulfide-linked complex in yeast mating.The Journal of biological chemistry · 2010Article
- The exomer coat complex transports Fus1p to the plasma membrane via a novel plasma membrane sorting signal in yeast.Molecular biology of the cell · 2009Article
- The class V myosin Myo2p is required for Fus2p transport and actin polarization during the yeast mating response.Molecular biology of the cell · 2009Article
- Enhanced fusion pore expansion mediated by the trans-acting Endodomain of the reovirus FAST proteins.PLoS pathogens · 2009Article
- Fusion-pore expansion during syncytium formation is restricted by an actin network.Journal of cell science · 2008Article
- Ergosterol promotes pheromone signaling and plasma membrane fusion in mating yeast.The Journal of cell biology · 2008Article
- Nuclear fusion during yeast mating occurs by a three-step pathway.The Journal of cell biology · 2007Article
- Detection of hyphal fusion in filamentous fungi using differently fluorescence-labeled histones.Current genetics · 2007Article
- Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae.Biochimica et biophysica acta · 2007Review
- Genetic control of fusion pore expansion in the epidermis of Caenorhabditis elegans.Molecular biology of the cell · 2007Article
- A role for a complex between activated G protein-coupled receptors in yeast cellular mating.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- The plasma membrane proteins Prm1 and Fig1 ascertain fidelity of membrane fusion during yeast mating.Molecular biology of the cell · 2007Article
- The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating.The Journal of cell biology · 2007Article
- Plasma membrane polarization during mating in yeast cells.The Journal of cell biology · 2006Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Mating yeast cells provide a genetically accessible system for the study of cell fusion. The dynamics of fusion pores between yeast cells were analyzed by following the exchange of fluorescent markers between fusion partners. Upon plasma membrane fusion, cytoplasmic GFP and DsRed diffuse between cells at rates proportional to the size of the fusion pore. GFP permeance measurements reveal that a typical fusion pore opens with a burst and then gradually expands. In some mating pairs, a sudden increase in GFP permeance was found, consistent with the opening of a second pore. In contrast, other fusion pores closed after permitting a limited amount of cytoplasmic exchange. Deletion of FUS1 from both mating partners caused a >10-fold reduction in the initial permeance and expansion rate of the fusion pore. Although fus1 mating pairs also have a defect in degrading the cell wall that separates mating partners before plasma membrane fusion, other cell fusion mutants with cell wall remodeling defects had more modest effects on fusion pore permeance. Karyogamy is delayed by >1 h in fus1 mating pairs, possibly as a consequence of retarded fusion pore expansion.
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