SynthesisEmerging infectious diseases2006
Systematic review of antimicrobial drug prescribing in hospitals.
Synthesis in Emerging infectious diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Association between adherence to an antimicrobial stewardship program and mortality among hospitalised cancer patients with febrile neutropaenia: a prospective cohort study.BMC infectious diseases · 2014Trial
- The effectiveness of intravenous (IV) to oral (PO) antibiotic switch (IVOS) interventions in managing community- and hospital-acquired pneumonia-a systematic review.JAC-antimicrobial resistance · 2026Review
- Development and Implementation of a Mobile Application for Choosing Empirical Antimicrobial Therapy for Bacteremia, Pneumonia, Urinary Tract Infection, and Skin and Soft Tissue Infection among Hospitalized Patients.Antibiotics (Basel, Switzerland) · 2023Article
- A prospective cluster trial to increase antibiotic prescription quality in seven non-ICU wards.GMS hygiene and infection control · 2023Article
- Assessment of Intravenous Antibiotics to Peroral Antibiotics Conversion Practice and Its Associated Factor at University of Gondar Comprehensive Specialized Hospital: Prospective Observational Study.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022Article
- Fighting AMR with Host Immune Response Technology.Drug discovery today · 2021Article
- Assessment of the Appropriateness of Ceftazidime Use in a Tertiary Teaching Hospital, Northern Ethiopia.Drug, healthcare and patient safety · 2019Article
- Observational multi-centre, prospective study to characterize novel pathogen-and host-related factors in hospitalized patients with lower respiratory tract infections and/or sepsis - the "TAILORED-Treatment" study.BMC infectious diseases · 2018Observational
- [Results of the implementation of an Antimicrobial Stewardship Program in the "Gerencia de Atención Integrada" of Alcazar de San Juan (Castilla La Mancha)].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2018Article
- A review of antimicrobial stewardship training in medical education.International journal of medical education · 2017Review
- The determinants of antimicrobial prescribing among hospital doctors in England: a framework to inform tailored stewardship interventions.British journal of clinical pharmacology · 2016Article
- The effectiveness and safety of two prophylactic antibiotic regimes in hip-fracture surgery.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2016Article
- Strategies to enhance rational use of antibiotics in hospital: a guideline by the German Society for Infectious Diseases.Infection · 2016Article
- Evaluation of ceftriaxone utilization in medical and emergency wards of Tikur Anbessa specialized hospital: a prospective cross-sectional study.BMC pharmacology & toxicology · 2016Article
- Impact of switching from intravenous to oral linezolid therapy in Japanese patients: a retrospective cohort study.Journal of pharmaceutical policy and practice · 2016Article
- Article
- If antibiotics did not exist.Intensive care medicine · 2015Article
- Antimicrobial stewardship in pediatrics: focusing on the challenges clinicians face.BMC pediatrics · 2014Article
- Association between Clostridium difficile infection and antimicrobial usage in a large group of English hospitals.British journal of clinical pharmacology · 2014Article
- Selection of hospital antimicrobial prescribing quality indicators: a consensus among German antibiotic stewardship (ABS) networkers.Infection · 2014Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Prudent prescribing of antimicrobial drugs to hospital inpatients may reduce incidences of antimicrobial drug resistance and healthcare-associated infection. We reviewed the literature from January 1980 to November 2003 to identify rigorous evaluations of interventions to improve hospital prescribing of antimicrobial drugs. We identified 66 studies with interpretable data, of which 16 reported 20 microbiologic outcomes: gram-negative resistant bacteria, 10 studies; Clostridium difficile-associated diarrhea, 5 studies; vancomycin-resistant enterococci, 3 studies; and methicillin-resistant Staphylococcus aureus, 2 studies. Four studies provided strong evidence that the intervention changed microbial outcomes with low risk for alternative explanations, 8 studies provided less convincing evidence, and 4 studies provided no evidence. The strongest and most consistent evidence was for C. difficile-associated diarrhea, but we were able to analyze only the immediate impact of interventions because of nonstandardized durations of follow-up. The ability to compare results of studies could be substantially improved by standardizing methods and reporting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.