ArticleMolecular and cellular biology1991
A novel Ca2+/calmodulin-dependent protein kinase and a male germ cell-specific calmodulin-binding protein are derived from the same gene.
Article in Molecular and cellular biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 135 citations in OpenAlex.
- CaMKIV negatively regulates osteoblast differentiation by modulating c-Fos and NFATc1 signaling: an in vitro and in vivo mechanistic study.BMB reports · 2026Article
- The Calcium/Calmodulin-Dependent Kinases II and IV as Therapeutic Targets in Neurodegenerative and Neuropsychiatric Disorders.International journal of molecular sciences · 2021Review
- Attenuated β-adrenergic response in calcium/calmodulin-dependent protein kinase IV-knockout mice.PloS one · 2021Article
- The Ca(2+)/Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft.Trends in endocrinology and metabolism: TEM · 2016Review
- Article
- Ca(2+)/Calmodulin-Dependent Protein Kinase IV Promotes Interplay of Proteins in Chromatoid Body of Male Germ Cells.Scientific reports · 2015Article
- Sisters Acts: Converging Signaling Between CaMKII and CaMKIV, Two Members of the Same Family.Translational medicine @ UniSa · 2012Article
- Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice.PloS one · 2010Article
- Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by group I metabotropic glutamate receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- A consensus CaMK IV-responsive RNA sequence mediates regulation of alternative exons in neurons.RNA (New York, N.Y.) · 2005Article
- Anion exchanger 2 is essential for spermiogenesis in mice.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Spermatogenesis and the regulation of Ca(2+)-calmodulin-dependent protein kinase IV localization are not dependent on calspermin.Molecular and cellular biology · 2001Article
- Impaired synaptic plasticity and cAMP response element-binding protein activation in Ca2+/calmodulin-dependent protein kinase type IV/Gr-deficient mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Activation of orphan receptor-mediated transcription by Ca(2+)/calmodulin-dependent protein kinase IV.The EMBO journal · 2000Article
- Two distinct forms of the 64,000 Mr protein of the cleavage stimulation factor are expressed in mouse male germ cells.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- alphaKAP is an anchoring protein for a novel CaM kinase II isoform in skeletal muscle.The EMBO journal · 1998Article
- The Epstein-Barr virus-induced Ca2+/calmodulin-dependent kinase type IV/Gr promotes a Ca(2+)-dependent switch from latency to viral replication.Journal of virology · 1997Article
- Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr.The Journal of experimental medicine · 1996Article
- The CREB, ATF-1, and ATF-2 transcription factors from bovine leukemia virus-infected B lymphocytes activate viral expression.Journal of virology · 1996Article
- An alternative, nonkinase product of the brain-specifically expressed Ca2+/calmodulin-dependent kinase II alpha isoform gene in skeletal muscle.Molecular and cellular biology · 1996Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
A cDNA representing a unique Ca2+/calmodulin-dependent protein kinase has been cloned and sequenced from a rat brain cDNA library. This enzyme, expressed in brain, testis, and spleen, is only 32% identical to the various isoforms of Ca2+/calmodulin-dependent protein kinase II. The sequence of the COOH-terminal 169 amino acids is identical to that of a previously described male germ cell-specific calmodulin-binding protein called calspermin (T. Ono, G.R. Slaughter, R.G. Cook, and A.R. Means, J. Biol. Chem. 264:2081-2087, 1989). This identity extends to the nucleic acid sequence and includes all but the first 130 nucleotides of the calspermin cDNA. Primer extension and sequence of a genomic fragment containing the unique calspermin sequence reveals that this mRNA is derived from the kinase transcription unit by germ cell-specific use of a unique exon. In situ hybridization was used to demonstrate that both kinase and calspermin mRNAs are expressed during spermatogenesis. The kinase mRNA is first detected in early meiotic cells and declines to a low level in haploid cells. Calspermin mRNA first appears in pachytene primary spermatocytes and continues to increase as cells complete meiosis and undergo terminal differentiation. These results show that differential utilization of a single gene during spermatogenesis is used to generate mRNAs that encode proteins with distinct functions.
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