Trial reportObesity (Silver Spring, Md.)2006
Muscle-associated triglyceride measured by computed tomography and magnetic resonance spectroscopy.
Trial report in Obesity (Silver Spring, Md.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02663362 (Development and Validation of Multi-nuclear Magnetic Resonance Imaging and Spectroscopy for Whole Body Human Applications), which is not on this map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development and Validation of Multi-nuclear Magnetic Resonance Imaging and Spectroscopy for Whole Body Human Applications
Who cites it
62 citing papers in PubMed, 110 citations in OpenAlex.
- Significant improvement in cardiometabolic health in healthy nonobese individuals during caloric restriction-induced weight loss and weight loss maintenance.American journal of physiology. Endocrinology and metabolism · 2018Trial
- Effects of 12 Months of Caloric Restriction on Muscle Mitochondrial Function in Healthy Individuals.The Journal of clinical endocrinology and metabolism · 2017Trial
- Differences in Mitochondrial Coupling Reveal a Novel Signature of Mitohormesis in Muscle of Healthy Individuals.The Journal of clinical endocrinology and metabolism · 2016Trial
- Spatial heterogeneity in the response of the proximal femur to two lower-body resistance exercise regimens.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Trial
- Aerobic exercise but not resistance exercise reduces intrahepatic lipid content and visceral fat and improves insulin sensitivity in obese adolescent girls: a randomized controlled trial.American journal of physiology. Endocrinology and metabolism · 2013Trial
- Water- versus land-based exercise in elderly subjects: effects on physical performance and body composition.Clinical interventions in aging · 2013Trial
- The effect of pioglitazone and resistance training on body composition in older men and women undergoing hypocaloric weight loss.Obesity (Silver Spring, Md.) · 2011Trial
- Characterization of the metabolic and physiologic response to chromium supplementation in subjects with type 2 diabetes mellitus.Metabolism: clinical and experimental · 2010Trial
- Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function.Obesity (Silver Spring, Md.) · 2008Trial
- Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects.Diabetes care · 2006Trial
- Age-related change in skeletal muscle strength, size, and adiposity over 18 years in Caribbean men.GeroScience · 2026Article
- Myosteatosis and Dyslipidemia: Linking Muscle Quality to Cardiometabolic Risk.Journal of lipid and atherosclerosis · 2026Review
- Longitudinal changes in body composition during palliative systemic chemotherapy and survival outcomes in metastatic colorectal cancer.World journal of gastrointestinal oncology · 2025Article
- Myosteatosis is associated with adiposity, metabolic derangements and mortality in patients with chronic kidney disease.European journal of clinical nutrition · 2025Article
- SARC-F as a screening tool to detect computed tomography-based sarcopenia and myosteatosis among older adults with cancer.Cancer medicine · 2023Article
- The Presence of Myosteatosis Is Associated with Age, Severity of Liver Disease and Poor Outcome and May Represent a Prodromal Phase of Sarcopenia in Patients with Liver Cirrhosis.Journal of clinical medicine · 2023Article
- The relationship between the mode of presentation, CT-derived body composition, systemic inflammatory grade and survival in colon cancer.Journal of cachexia, sarcopenia and muscle · 2022Article
- Modifications of Chest CT Body Composition Parameters at Three and Six Months after Severe COVID-19 Pneumonia: A Retrospective Cohort Study.Nutrients · 2022Article
- Fatty Liver Index and Skeletal Muscle Density.Calcified tissue international · 2022Article
- Impact of Sarcopenia and Myosteatosis in Non-Cirrhotic Stages of Liver Diseases: Similarities and Differences across Aetiologies and Possible Therapeutic Strategies.Biomedicines · 2022Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveMuscle triglyceride can be assessed in vivo using computed tomography (CT) and 1H magnetic resonance spectroscopy (MRS), two techniques that are based on entirely different biophysical principles. Little is known, however, about the cross-correlation between these techniques and their test-retest reliability. RESEARCH METHODS AND PROCEDURES: We compared mean muscle attenuation (MA) in soleus and tibialis anterior (TA) muscles measured by CT with intra- and extramyocellular lipids (IMCL and EMCL, respectively) measured by MRS in 51 volunteers (26 to 72 years of age, BMI = 25.5 to 39.3 kg/m2). MA of midthighs was also measured in a subset (n = 19). Test-retest measurements were performed by CT (n = 6) and MRS (n = 10) in separate sets of volunteers.
resultsMA of soleus was significantly associated with IMCL (r = -0.64) and EMCL, which by multiple regression analysis was explained mostly by IMCL (p < 0.001) rather than EMCL (beta = -0.010, p = 0.94). Muscle triglyceride was lower in TA than in soleus, and MA of TA was significantly correlated with EMCL (r = -0.40) but not IMCL (r = -0.16). By CT, MA of midthighs was correlated with MA in soleus (r = 0.40, p = 0.07) and whole calf (r = 0.62, p < 0.05). Finally, both MA and IMCL were highly reliable in soleus (coefficient of variation = < 2% and 6.7%, respectively) and less reliable in TA (4% and 10%, respectively). DISCUSSION: These results support the use of both CT and MRS as reliable methods for assessing skeletal muscle lipid.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.