ArticleProceedings of the National Academy of Sciences of the United States of America2006
Base-tetrad swapping results in dimerization of RNA quadruplexes: implications for formation of the i-motif RNA octaplex.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Elucidating the solution structure of the monomolecularChemical science · 2025Article
- Non-G Base Tetrads.Molecules (Basel, Switzerland) · 2022Review
- Structural motifs and intramolecular interactions in non-canonical G-quadruplexes.RSC chemical biology · 2021Review
- The origin of the high stability of 3'-terminal uridine tetrads: contributions of hydrogen bonding, stacking interactions, and steric factors evaluated using modified oligonucleotide analogs.RNA (New York, N.Y.) · 2020Article
- Unraveling the structural basis for the exceptional stability of RNA G-quadruplexes capped by a uridine tetrad at the 3' terminus.RNA (New York, N.Y.) · 2019Article
- Structure and hydrodynamics of a DNA G-quadruplex with a cytosine bulge.Nucleic acids research · 2018Article
- An intercalation-locked parallel-stranded DNA tetraplex.Nucleic acids research · 2015Article
- Crystal structure of a DNA/Ba2+ G-quadruplex containing a water-mediated C-tetrad.Nucleic acids research · 2014Article
- Distinctive structural motifs of RNA G-quadruplexes composed of AGG, CGG and UGG trinucleotide repeats.Nucleic acids research · 2014Article
- Assessing diversity of DNA structure-related sequence features in prokaryotic genomes.DNA research : an international journal for rapid publication of reports on genes and genomes · 2014Article
- Structural basis for promutagenicity of 8-halogenated guanine.The Journal of biological chemistry · 2014Article
- Guanine base stacking in G-quadruplex nucleic acids.Nucleic acids research · 2013Article
- Differential stabilization of adenine quartets by anions and cations.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2010Article
- Predictable suppression of gene expression by 5'-UTR-based RNA quadruplexes.Nucleic acids research · 2009Article
- Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics.Nucleic acids research · 2007Review
- DNA architecture: from G to Z.Current opinion in structural biology · 2006Review
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3 authors.
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Abstract
Nucleic acids adopt different multistranded helical architectures to perform various biological functions. Here, we report a crystal structure of an RNA quadruplex containing "base-tetrad swapping" and bulged nucleotide at 2.1-Angstroms resolution. The base-tetrad swapping results in a dimer of quadruplexes with an intercalated octaplex fragment at the 5' end junction. The intercalated base tetrads provide the basic repeat unit for constructing a model of intercalated RNA octaplex. The model we obtained shows fundamentally different characteristics from duplex, triplex, and quadruplex. We also observed two different orientations of bulged uridine residues that are related to the interaction with surroundings. This structural evidence reflects the conformational flexibility of bulged nucleotides in RNA quadruplexes and implies the potential roles of bulged nucleotides as recognition and interaction sites in RNA-protein and RNA-RNA interactions.
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