ArticleProceedings of the National Academy of Sciences of the United States of America2006
Proteomic analysis of adaptor protein 1A coats selectively assembled on liposomes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 52 citations in OpenAlex.
- The AP-1 adaptor complex is essential for intracellular trafficking of the ORF2 capsid protein and assembly of Hepatitis E virus.Cellular and molecular life sciences : CMLS · 2024Article
- Arf GTPase activates the WAVE regulatory complex through a distinct binding site.Science advances · 2022Article
- Perspective of the GEMSTONE Consortium on Current and Future Approaches to Functional Validation for Skeletal Genetic Disease Using Cellular, Molecular and Animal-Modeling Techniques.Frontiers in endocrinology · 2021Review
- APP controls the formation of PI(3,5)P(2) vesicles through its binding of the PIKfyve complex.Cellular and molecular life sciences : CMLS · 2016Article
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- The Amyloid Precursor Protein Controls PIKfyve Function.PloS one · 2015Article
- Adaptor Protein 1A Facilitates Dengue Virus Replication.PloS one · 2015Article
- Steering cell migration: lamellipodium dynamics and the regulation of directional persistence.Nature reviews. Molecular cell biology · 2014Review
- GOLPH3 is essential for contractile ring formation and Rab11 localization to the cleavage site during cytokinesis in Drosophila melanogaster.PLoS genetics · 2014Article
- Rho GTPases, phosphoinositides, and actin: a tripartite framework for efficient vesicular trafficking.Small GTPases · 2014Review
- WAVE/SCAR promotes endocytosis and early endosome morphology in polarized C. elegans epithelia.Developmental biology · 2013Article
- Rac and Rab GTPases dual effector Nischarin regulates vesicle maturation to facilitate survival of intracellular bacteria.The EMBO journal · 2013Article
- The clathrin adaptor AP-1A mediates basolateral polarity.Developmental cell · 2012Article
- Bridging membrane and cytoskeleton dynamics in the secretory and endocytic pathways.Nature cell biology · 2011Review
- A novel role for retromer in the control of epithelial cell polarity.Communicative & integrative biology · 2011Article
- WAVE regulatory complex activation by cooperating GTPases Arf and Rac1.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
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- Article
- Rab14 from Bombyx mori (Lepidoptera: Bombycidae) shows ATPase activity.Biology letters · 2010Article
- AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory.The EMBO journal · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coat components localize to specific membrane domains, where they sort selected transmembrane proteins. To study how clathrin coats are stabilized on such domains and to identify the protein networks involved, we combined proteomic screens and in vitro liposome-based assays that recapitulate the fidelity of protein sorting in vivo. Our study identifying approximately 40 proteins on AP-1A-coated liposomes revealed that AP-1A coat assembly triggers the concomitant recruitment of Rac1, its effectors, and the Wave/Scar complex as well as that of Rab11 and Rab14. The coordinated recruitment of these different machineries requires a mosaic of membrane components comprising the GTPase ADP-ribosylation factor 1, sorting signals in selected transmembrane proteins, and phosphatidylinositol 4-phosphate. These results demonstrate that the combinatorial use of low-affinity binding sites present on the same membrane domain accounts not only for a selective coat assembly but also for the coordinated assembly of selected machineries required for actin polymerization and subsequent membrane fusion.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.