ArticleThe Journal of cell biology1991
Cell-cell contacts mediated by E-cadherin (uvomorulin) restrict invasive behavior of L-cells.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 228 citations in OpenAlex.
- Regulation of epithelial cell jamming transition by cytoskeleton and cell-cell interactions.Biophysics reviews · 2024Review
- An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion.Developmental cell · 2023Article
- Disentangling cadherin-mediated cell-cell interactions in collective cancer cell migration.Biophysical journal · 2022Article
- Function of hepatocyte growth factor in gastric cancer proliferation and invasion.Yeungnam University journal of medicine · 2020Article
- E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms.Molecular cancer research : MCR · 2019Article
- Cadherin Signaling in Cancer: Its Functions and Role as a Therapeutic Target.Frontiers in oncology · 2019Review
- Prognostic significance and biological function of Lamina-associated polypeptide 2 in non-small-cell lung cancer.OncoTargets and therapy · 2019Article
- Cancer as an Embryological Phenomenon and Its Developmental Pathways: A Hypothesis regarding the Contribution of the Noncanonical Wnt Pathway.TheScientificWorldJournal · 2019Review
- Review
- Mechanisms and in vivo functions of contact inhibition of locomotion.Nature reviews. Molecular cell biology · 2017Review
- MT2-MMP induces proteolysis and leads to EMT in carcinomas.Oncotarget · 2016Article
- Vertebrate Claudin/PMP22/EMP22/MP20 family protein TMEM47 regulates epithelial cell junction maturation and morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Molecular basis of contact inhibition of locomotion.Cellular and molecular life sciences : CMLS · 2016Review
- Retrospective analysis of metastatic behaviour of breast cancer subtypes.Breast cancer research and treatment · 2015Article
- Regulation of contact inhibition of locomotion by Eph-ephrin signalling.Journal of microscopy · 2013Review
- Overexpression of snail induces epithelial-mesenchymal transition and a cancer stem cell-like phenotype in human colorectal cancer cells.Cancer medicine · 2012Article
- E-cadherin is critical for collective sheet migration and is regulated by the chemokine CXCL12 protein during restitution.The Journal of biological chemistry · 2012Article
- Article
- Plakoglobin: role in tumorigenesis and metastasis.International journal of cell biology · 2012Article
- Periostin expression and epithelial-mesenchymal transition in cancer: a review and an update.Virchows Archiv : an international journal of pathology · 2011Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
L-cells were cotransfected with plasmids coding for mouse E-cadherin (uvomorulin) and the neophosphotransferase gene, and stable transfectants expressing E-cadherin at the cell surface were selected and cloned. Control transfection was done with the neophosphotransferase gene alone. The invasive migration of transfected and untransfected L-cells into three-dimensional collagen gels was then analyzed. L-cells not expressing E-cadherin migrated efficiently into the gels, whereas invasion of the E-cadherin-expressing L-cells was restricted in a cell density dependent manner. At sparse density, when the cells exhibited little cell-cell contacts, no difference was observed between the level of invasion of the cadherin-expressing cells and the control cells. However, with increasing cell density, decreasing amounts of the cadherin-expressing cells but increasing amounts of the control cells migrated into the gels. At confluent density hardly any cadherin-expressing cells were able to migrate into the gels. The inhibition of the invasion of the cadherin-expressing cells could be reverted if confluent cells were cultured in the presence of monoclonal antibodies against E-cadherin. Since the expression of E-cadherin did not influence the invasive mobility of single cells, these results indicate that E-cadherin-mediated cell-cell contacts inhibited invasive cellular migration. Time-lapse videoscopy and studies of cell migration from a monolayer into a cell-free area demonstrated that the restricted invasion could be explained by contact inhibition of cell movement of the cadherin-expressing cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.