ArticleThe Journal of cell biology1991
The ryanodine receptor/junctional channel complex is regulated by growth factors in a myogenic cell line.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 44 citations in OpenAlex.
- The binding interactions that maintain excitation-contraction coupling junctions in skeletal muscle.The Journal of general physiology · 2019Article
- Evidence for conformational coupling between two calcium channels.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- FGF-8 in the ventral pharynx alters development of myocardial calcium transients after neural crest ablation.The Journal of clinical investigation · 2001Article
- Triad proteins and intracellular Ca2+ transients during development of human skeletal muscle cells in aneural and innervated cultures.Journal of muscle research and cell motility · 2000Article
- Coordinated incorporation of skeletal muscle dihydropyridine receptors and ryanodine receptors in peripheral couplings of BC3H1 cells.The Journal of cell biology · 1997Article
- Differential expression of ryanodine receptor RyR2 mRNA in the non-pregnant and pregnant human myometrium.The Biochemical journal · 1997Article
- Formation of junctions involved in excitation-contraction coupling in skeletal and cardiac muscle.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Co-expression in CHO cells of two muscle proteins involved in excitation-contraction coupling.Journal of muscle research and cell motility · 1995Article
- Involvement of dihydropyridine receptors in terminating Ca2+ release in rat skeletal myotubes.The Journal of physiology · 1995Article
- Abnormal junctions between surface membrane and sarcoplasmic reticulum in skeletal muscle with a mutation targeted to the ryanodine receptor.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Kinetic properties of skeletal-muscle-like high-threshold calcium currents in a non-fusing muscle cell line.Pflugers Archiv : European journal of physiology · 1994Article
- Development of the excitation-contraction coupling apparatus in skeletal muscle: peripheral and internal calcium release units are formed sequentially.Journal of muscle research and cell motility · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The ryanodine receptor/junctional channel complex (JCC) forms the calcium release channel and foot structures of the sarcoplasmic reticulum. The JCC and the dihydropyridine (DHP) receptor in the transverse tubule are two of the major components involved in excitation-contraction (E-C) coupling in skeletal muscle. The DHP receptor is believed to serve as the voltage sensor in E-C coupling. Both the JCC and DHP receptor, as well as many skeletal muscle-specific contractile protein genes, are expressed in the BC3H1 muscle cell line. In the present study, we find that during differentiation of BC3H1 cells, induced by mitogen withdrawal, induction of the JCC and DHP receptor mRNAs is temporally similar to that of the skeletal muscle contractile protein genes alpha-tropomyosin and alpha-actin. Our data suggest that there is coordinate regulation of both the contractile protein genes (which have been studied in detail previously) and the genes encoding the calcium channels involved in E-C coupling. Induction of both calcium channels is accompanied by profound changes in BC3H1 cell morphology including the development of many components of mature skeletal muscle cells, despite lack of myoblast fusion. Visualized by electron microscopy, the JCC appears as "foot structures" located in the dyad junction between the plasmalemma and the sarcoplasmic reticulum of the BC3H1 cells. Development of foot structures is concomitant with JCC mRNA expression. Expression of the JCC and DHP receptor mRNAs and formation of the foot structures are inhibited specifically by fibroblast growth factor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.