ArticleIntegrative physiological and behavioral science : the official journal of the Pavlovian Society
Leverpress escape/avoidance training increases neurotrophin levels in rat brain.
Article in Integrative physiological and behavioral science : the official journal of the Pavlovian Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 7 citations in OpenAlex.
- Inhibition of corticosterone synthesis impairs cued water maze consolidation, but it does not affect the expression of BDNF, CK2 and SGK1 genes in dorsal striatum.Frontiers in behavioral neuroscience · 2024Article
- Selective Activation of Striatal NGF-TrkA/p75NTR/MAPK Intracellular Signaling in Rats That Show Suppression of Methamphetamine Intake 30 Days following Drug Abstinence.The international journal of neuropsychopharmacology · 2018Article
- Sign-tracking to an appetitive cue predicts incubation of conditioned fear in rats.Behavioural brain research · 2015Article
- Intense exercise induces mitochondrial dysfunction in mice brain.Neurochemical research · 2008Article
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Authors and funding
5 authors at 3 institutions in 1 country.
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Abstract
In addition to their well-known role in neural development, the neurotrophins BDNF and NGF help mediate the plasticity that occurs in the brain to promote learning. Exposure to learning procedures often leads to increases in neurotrophins, while exposure to stress often results in decreases. It is unclear how the neurotrophins would respond to an aversive learning task. Therefore, BDNF and NGF content in the dorsal striatum, hippocampus, and basal forebrain was measured following discrete trial lever-press escape/avoidance conditioning. Conditioning significantly increased levels of both neurotrophins in hippocampus and basal forebrain, relative to home cage controls (HCC). Contrary to expectations, the dorsal striatum did not show any significant changes. However, significant correlations were observed between dorsal striatal neurotrophins and aspects of avoidance performance. This may indicate that the dorsal striatum is involved in the performance aspects of the task. Results are discussed in terms of the role of neurotrophins in the acquisition of new information, and the neural structures involved in different types of memory.
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Registered trials
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