ArticleEuropean journal of nuclear medicine and molecular imaging2006
Comparison of 111In-DOTA-DPhe1-Tyr3-octreotide and 111In-DOTA-lanreotide scintigraphy and dosimetry in patients with neuroendocrine tumours.
Article in European journal of nuclear medicine and molecular imaging, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- The joint IAEA, EANM, and SNMMI practical guidance on peptide receptor radionuclide therapy (PRRNT) in neuroendocrine tumours.European journal of nuclear medicine and molecular imaging · 2013Guideline
- Specific Targeting of Somatostatin Receptor Subtype-2 for Fluorescence-Guided Surgery.Clinical cancer research : an official journal of the American Association for Cancer Research · 2019Article
- Novel PET tracers: added value for endocrine disorders.Endocrine · 2019Review
- Somatostatin receptor PET ligands - the next generation for clinical practice.American journal of nuclear medicine and molecular imaging · 2018Review
- A Modular Dual-Labeling Scaffold That Retains Agonistic Properties for Somatostatin Receptor Targeting.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2017Article
- Patient-specific dosimetry ofEJNMMI physics · 2017Article
- Cardiothoracic manifestations of neuroendocrine tumours.The British journal of radiology · 2016Review
- Pulmonary Large-Cell Neuroendocrine Carcinoma: From Epidemiology to Therapy.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2015Article
- Somatostatin receptor PET in neuroendocrine tumours: 68Ga-DOTA0,Tyr3-octreotide versus 68Ga-DOTA0-lanreotide.European journal of nuclear medicine and molecular imaging · 2013Article
- Article
- Biokinetics and dosimetry of commonly used radiopharmaceuticals in diagnostic nuclear medicine - a review.European journal of nuclear medicine and molecular imaging · 2011Review
- Concordance between results of somatostatin receptor scintigraphy with 111In-DOTA-DPhe 1-Tyr 3-octreotide and chromogranin A assay in patients with neuroendocrine tumours.European journal of nuclear medicine and molecular imaging · 2008Article
- Peptidyl molecular imaging contrast agents using a new solid-phase peptide synthesis approach.Bioconjugate chemistryArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSomatostatin receptor scintigraphy with (111)In-DOTA-D: Phe(1)-Tyr(3)-octreotide ((111)In-DOTA-TOC) and (111)In-DOTA-lanreotide ((111)In-DOTA-LAN) has been used for staging of neuroendocrine tumours (NETs). However, the comparative diagnostic value of these radioligands on a lesion basis has not yet been established. The aim of this study was to compare the diagnostic capacity of (111)In-DOTA-TOC and (111)In-DOTA-LAN scintigraphy in patients with NETs, evaluating whether significant differences exist in lesion imaging with these radioligands. Furthermore, dosimetric data were compared.
methodsForty-five patients with NETs were investigated with (111)In-DOTA-TOC and (111)In-DOTA-LAN scintigraphy. Scintigraphic results were compared with those of conventional imaging and/or surgery in each patient, and also (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in 20 patients.
results(111)In-DOTA-TOC and (111)In-DOTA-LAN scintigraphy were true positive in 42/45 (93%) and 39/45 (87%) patients, and imaged 74/91 (81%) and 73/91 (80%) tumour lesions, respectively. (111)In-DOTA-TOC and (111)In-DOTA-LAN detected liver metastases in 21 and 14 patients, mediastinal metastases in seven and 11 patients, and bone metastases in two and seven patients, respectively. These radioligands revealed lesions not seen by conventional imaging in seven and eight patients, respectively, or by (18)F-FDG-PET in eight and seven patients, respectively. The estimated tumour absorbed doses for (90)Y-DOTA-TOC were higher than those for (90)Y-DOTA-LAN in 14 patients, whereas the opposite was true in 12 patients.
conclusionBoth (111)In-DOTA-TOC and (111)In-DOTA-LAN are suitable for imaging tumour lesions in patients with NETs and can detect lesions that may not be seen by conventional imaging and (18)F-FDG-PET. Compared with (111)In-DOTA-LAN, (111)In-DOTA-TOC has a superior diagnostic capacity for liver metastases, but a lower diagnostic capacity for metastatic lesions in mediastinum and bone.
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