ArticleDiabetologia2006
Inverse relationship between allergic contact dermatitis and type 1 diabetes mellitus: a retrospective clinic-based study.
Article in Diabetologia, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 29 citations in OpenAlex.
- Similar Skin Barrier Function in Persons with Type 1 Diabetes Compared with Healthy Controls.JID innovations : skin science from molecules to population health · 2023Article
- Contact Dermatitis: Overcoming Challenges of Specific Patients, Deciphering the Results and Reaching a Correct Diagnosis.Handbook of experimental pharmacology · 2022Article
- Adhesives Used for Diabetes Medical Devices: A Neglected Risk With Serious Consequences?Journal of diabetes science and technology · 2016Article
- Analysis of selected allergic reactions among psoriatic patients.Postepy dermatologii i alergologii · 2016Article
- Systemic immunogenicity of para-Phenylenediamine and Diphenylcyclopropenone: two potent contact allergy-inducing haptens.Immunologic research · 2014Article
- Impaired hapten sensitization in patients with autoimmune disease.Clinical and experimental immunology · 2011Article
- Article
- Prevention of diabetes in NOD mice by repeated exposures to a contact allergen inducing a sub-clinical dermatitis.PloS one · 2010Article
- The association between metal allergy, total hip arthroplasty, and revision.Acta orthopaedica · 2009Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisContact allergy (CA) is a disease induced and maintained by environmental factors, which mainly has a Th2 pattern in its chronic form. Environmental factors play a major role in CA, while genetic factors are of minor importance. Type 1 diabetes is an autoimmune disease of the islets of Langerhans, which has a Th1 cytokine pattern and in which modulators of risk are both genetic and environmental. To investigate whether environmental exposure to chemicals leading to CA could influence the risk of type 1 diabetes, we conducted a retrospective clinic-based study of patients subjected to diagnostic patch testing of CA.
methodsWe undertook a retrospective clinic-based study of 13,315 patients who were patch-tested between 1985 and 2003, and linked it with the Danish National Patient Registry containing diabetic mellitus discharge diagnoses from 1987 to 2003. The 13,315 patch-tested patients gave rise to 4,848 CA patients. Using logistic regression, we calculated odds ratios for persons with CA of having type 1 diabetes.
resultsType 1 diabetes was diagnosed in 229 of the patch-tested patients. CA patients had a reduced risk of having type 1 diabetes, with an odds ratio 0.62 (95% CI 0.46-0.86). After adjusting for sex and age, the odds ratio was 0.63 (95% CI 0.47-0.86). CONCLUSIONS/
interpretationAn inverse relationship between CA and type 1 diabetes was found. Thus there may be a protective effect of having CA in relation to the risk of type 1 diabetes, or vice versa type 1 diabetes may lead to tolerance rather than hypersensitivity. Alternatively, these two diseases may share common genetic factors, although at present these are unknown.
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