ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2006
Symptom clusters in cancer patients.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 159 citations in OpenAlex.
- A literature synthesis of symptom prevalence and severity in persons receiving active cancer treatment.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013Pooled it
- A review of the prevalence and impact of multiple symptoms in oncology patients.Journal of pain and symptom management · 2009Pooled it
- Neurobehavioral effects of interferon-α in patients with hepatitis-C: symptom dimensions and responsiveness to paroxetine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Trial
- Mindfulness based stress reduction in post-treatment breast cancer patients: an examination of symptoms and symptom clusters.Journal of behavioral medicine · 2012Trial
- Response analysis for multiple symptoms revealed differences between arms of a symptom management trial.Journal of clinical epidemiology · 2009Trial
- Longitudinal symptom dynamics in postoperative patients with liver cancer: A cross-lagged panel network analysis.Asia-Pacific journal of oncology nursing · 2026Article
- Medical and psychosocial symptom clusters and their temporal patterns in people with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- The Potential of Normobaric Oxygen Therapy to Enhance Erythropoiesis, Reduce Oxidative Stress, and Modulate Immune Function in Colorectal Cancer Patients Undergoing Chemotherapy: Study Protocol for a Prospective, Randomized, Double-Blind, Placebo-Controlled Trial (NBO-ONCO).Journal of clinical medicine · 2025Article
- Two-part sequential measurement models for distinguishing between symptom presence and symptom severity.Behavior research methods · 2025Article
- Impact of Multimorbidity on Symptom Burden and Symptom Clusters in Patients Receiving Chemotherapy.Cancer medicine · 2025Article
- Identifying symptom cluster in cancer patients undergoing chemotherapy-in Vietnam: A cross-sectional study.PloS one · 2024Article
- Cumulative burden of symptomatology in patients with gynecologic malignancies undergoing chemotherapy.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2022Article
- Symptom clusters in outpatients with cancer using different dimensions of the symptom experience.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Symptom clusters and their predictors in patients with lung cancer and treated with programmed cell death protein 1 immunotherapy.Asia-Pacific journal of oncology nursing · 2022Article
- The characteristics and related factors of insomnia among postoperative patients with gastric cancer: a cross-sectional survey.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Mind-Body Therapies for Cancer Patients Living with Depression, Anxiety or Insomnia (MIRACLE): A Systematic Review with Individual Participant Data Network Meta-Analysis.Methods and protocols · 2021Article
- Symptom trajectories during chemotherapy in patients with non-small cell lung cancer (NSCLC) and the function of prolonging low dose dexamethasone in promoting enhanced recovery after chemotherapy.Thoracic cancer · 2021Article
- A Proposed Theory of Symptom Cluster Management.Belitung nursing journal · 2021Article
- New-onset insomnia among cancer patients undergoing chemotherapy: prevalence, risk factors, and its correlation with other symptoms.Sleep & breathing = Schlaf & Atmung · 2020Article
- Facing the large variety of life-limiting conditions in children.European journal of pediatrics · 2019Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
goals of workCancer patients often experience multiple symptoms, many of which have been reported to correlate with each other. The goals of this study were to understand which cancer-related symptoms cluster together and to test the conceptual meanings of the revealed symptom clusters. PATIENTS AND
methodsPatients with various cancer diagnoses (N=151) were recruited from a medical center in northern Taiwan. The 13-item M.D. Anderson symptom inventory was used to assess patients' symptom severity. Selected symptoms were factored using principal-axis factoring with oblique rotation. The known-group technique was used to validate the conceptual meanings of revealed factors. MAIN
resultsPatients' symptom severity ratings fit a three-factor solution that explained 55% of the variance. These three factors (symptom clusters) were named sickness symptom cluster, gastrointestinal symptom cluster, and emotional symptom cluster. Patients with pain and with advanced diseases had significantly higher mean scores in the sickness symptom cluster than patients without pain and with earlier-stage diseases. The patients' functional status was negatively correlated with mean scores in the sickness symptom cluster. Patients under chemotherapy demonstrated significantly higher mean scores in the gastrointestinal symptom cluster than patients under other treatments. Patients with anxiety or depression also had significantly higher mean scores in the emotional symptom cluster than patients without anxiety or depression.
conclusionsThis study identified three underlying symptom clusters and verified their conceptual meaning in cancer patients. Knowing these symptom clusters may help healthcare professionals understand plausible mechanisms for the aggregation of symptoms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.