ArticleImmunology1991
The accumulation of 111In-eosinophils induced by inflammatory mediators, in vivo.
Article in Immunology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 92 citations in OpenAlex.
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- Hyaluronidase decreases neutrophils infiltration to the inflammatory site.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality.Nature communications · 2016Article
- The leukotriene B₄/BLT₁ axis is a key determinant in susceptibility and resistance to histoplasmosis.PloS one · 2014Article
- Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2.Inflammation · 2013Article
- Eosinophil recruitment and activation: the role of lipid mediators.Frontiers in pharmacology · 2013Article
- Leukotriene B4-loaded microspheres: a new therapeutic strategy to modulate cell activation.BMC immunology · 2008Article
- Levels of IL-8 and myeloperoxidase in the lungs of pneumonia patients.Molecular and cellular biochemistry · 2001Article
- Leukotrienes are involved in leukocyte recruitment induced by live Histoplasma capsulatum or by the beta-glucan present in their cell wall.British journal of pharmacology · 1999Article
- A comparison of the inhibitory activity of PDE4 inhibitors on leukocyte PDE4 activity in vitro and eosinophil trafficking in vivo.British journal of pharmacology · 1999Article
- Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils.The Journal of experimental medicine · 1998Article
- Chemokine-induced eosinophil recruitment. Evidence of a role for endogenous eotaxin in an in vivo allergy model in mouse skin.The Journal of clinical investigation · 1997Article
- Kinetics of eotaxin generation and its relationship to eosinophil accumulation in allergic airways disease: analysis in a guinea pig model in vivo.The Journal of experimental medicine · 1997Article
- Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice.The Journal of clinical investigation · 1997Article
- Effects of dexamethasone and cyclosporin A on the accumulation of eosinophils in acute cutaneous inflammation in the guinea-pig.British journal of pharmacology · 1996Article
- Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo.The Journal of experimental medicine · 1995Article
- Substance P-induced inflammatory responses in guinea-pig skin: the effect of specific NK1 receptor antagonists and the role of endogenous mediators.British journal of pharmacology · 1995Article
- LPS-induced 111In-eosinophil accumulation in guinea-pig skin: evidence for a role for TNF-alpha.Immunology · 1995Article
- Studies on the mechanisms involved in the inflammatory response in a reversed passive Arthus reaction in guinea-pig skin: contribution of neutrophils and endogenous mediators.British journal of pharmacology · 1994Article
- Differential effects of the PAF receptor antagonist UK-74,505 on neutrophil and eosinophil accumulation in guinea-pig skin.British journal of pharmacology · 1994Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eosinophils are implicated in the pathogenesis of a variety of allergic inflammatory diseases such as asthma. Several substances have been shown to be chemotactic for eosinophils in vitro, but the inflammatory mediators involved in the accumulation of eosinophils in vivo are as yet unidentified. In this study we have developed a system to measure the accumulation of 111In-eosinophils in guinea-pig skin in vivo. Horse serum-induced guinea-pig peritoneal eosinophils were radiolabelled with 111In and injected intravenously into recipient animals. 125I-albumin was also injected intravenously in order to measure local oedema formation simultaneously. A range of putative mediators was injected intradermally and responses measured for up to 2 hr. Of the mediators tested, guinea-pig C5a des Arg in zymosan-activated plasma was the most active. Recombinant human C5a (rHC5a) was also highly active, but less than the guinea-pig material. C5a des Arg in maximally activated plasma induced a 1500% increase in eosinophil accumulation, while rHC5a (10(-10) mol dose) induced a 600% increase. Platelet-activating factor (PAF) and leukotriene B4 (LTB4) were also tested for comparison. With respect to 111In-eosinophil accumulation, the order of potency of the mediators tested was as follows: guinea-pig C5a des Arg greater than LTB4 greater than PAF. In contrast, the order of potency of the mediators with respect to oedema formation was: PAF greater than guinea-pig C5a des Arg greater than LTB4. The techniques described will facilitate analysis of the mechanisms involved in eosinophil accumulation in defined inflammatory reactions.
Indexed as
Identifiers
1649126PMC1384469W2411461276What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.