ArticleImmunology1991
Modulation of phagocytic function in murine peritoneal macrophages by bombesin, gastrin-releasing peptide and neuromedin C.
Article in Immunology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 105 citations in OpenAlex.
- Advances of radiolabeled GRPR ligands for PET/CT imaging of cancers.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Review
- Review
- Radiation-induced lung injury is mitigated by blockade of gastrin-releasing peptide.The American journal of pathology · 2013Article
- Gastrin-releasing peptide receptor (GRPR) mediates chemotaxis in neutrophils.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Gastrin-releasing peptide blockade as a broad-spectrum anti-inflammatory therapy for asthma.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Effects of the gastrin-releasing peptide antagonist RC-3095 in a rat model of ulcerative colitis.Digestive diseases and sciences · 2010Article
- Tumor-associated macrophages in clear cell renal cell carcinoma express both gastrin-releasing peptide and its receptor: a possible modulatory role of immune effectors cells.World journal of urology · 2010Article
- Gastrin-releasing peptide links stressor to cancer progression.Journal of cancer research and clinical oncology · 2010Review
- International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states.Pharmacological reviews · 2008Review
- Gastrin releasing peptide receptor expression is decreased in patients with Crohn's disease but not in ulcerative colitis.Journal of clinical pathology · 2004Article
- Immunomodulatory functions of the diffuse neuroendocrine system: implications for bronchopulmonary dysplasia.Endocrine pathology · 2004Review
- Stimulation of murine peritoneal macrophage functions by neuropeptide Y and peptide YY. Involvement of protein kinase C.Immunology · 1993Article
- Stimulation of the phagocytic function in guinea pig peritoneal macrophages by physical activity stress.European journal of applied physiology and occupational physiology · 1992Article
- Leupaxin is similar to paxillin in focal adhesion targeting and tyrosine phosphorylation but has distinct roles in cell adhesion and spreading.Cell adhesion & migrationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bombesin, as well as the two mammalian bombesin-like peptides gastrin-releasing peptide and neuromedin C, have been shown in this study to stimulate in vitro all steps of the phagocytic process in murine peritoneal macrophages: adherence to substrate, chemotaxis, ingestion of cells (Candida albicans) and inert particles (latex beads), and production of superoxide anion as measured by nitroblue tetrazolium reduction. A dose-response relationship was observed, with maximal stimulation of phagocytic process between 10(-12)M and 10(-9)M. Gastrin-releasing peptide (GRP) and neuromedin C caused a higher activation of adherence, chemotaxis and ingestion of C. albicans than bombesin. The three neuropeptides induced in murine macrophages a significant, but transient, increase of inositol 1,4,5-trisphosphate (IP3) levels at 60 seconds. On the contrary, these neuropeptides produced a rapid, transient and significant decrease of cAMP at 30 seconds. These results suggest that there are close relations between IP3 and cAMP messenger systems and the phagocytic process in murine peritoneal macrophages when these cells are incubated in the presence of bombesin, GRP or neuromedin C.
Indexed as
Identifiers
1649124PMC1384466W2235638086What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.