Evidence map›Paper›PMID 16490353›Full record

ReviewTrends in cell biology2006

Pathways and control of connexin oligomerization.

Michael Koval

Open access · bronzeAbstract readReview
In one paragraph

Review in Trends in cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 134 citations in OpenAlex.

  1. Beyond the gap: moonlighting functions of connexins in cancer.Cell communication and signaling : CCS · 2026
    Review
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  14. Frontiers in cell and developmental biology · 2023
    Article
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  16. Review
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Michael KovalDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. mhkoval@emory.edu
Emory University · US

Funding

UPTAKE AND REUTILIZATION OF SURFACTANT COMPONENTSP01HL019737 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI FISHER, ARON B. · 1985 to 2013
$23.6M
CONTROL OF CONNEXIN TRANSPORT AND ASSEMBLYR01GM061012 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KOVAL, MICHAEL H. · 2000 to 2004
$1.1M
NHLBI NIH HHS P01 HL019737NHLBI NIH HHS P01 HL 019737-26NIGMS NIH HHS GM 61012NIGMS NIH HHS R01 GM061012
6 · The paper itself

Abstract

Connexins form gap junction channels that link neighboring cells into an intercellular communication network. Many cells that express multiple connexins produce heteromeric channels containing at least two connexins, which provides a means to fine tune gap junctional communication. Formation of channels by multiple connexins is controlled at two levels: by inherent structural compatibilities that enable connexins to hetero-oligomerize and by cellular mechanisms that restrict the formation of heteromers by otherwise compatible connexins. Here, I discuss roles for secretory compartments beyond the endoplasmic reticulum in connexin oligomerization and evidence that suggests that membrane microdomains help regulate connexin trafficking and assembly.

Indexed as

AnimalsCell CommunicationConnexinsEndoplasmic ReticulumGap JunctionsLysineMembrane MicrodomainsModels, MolecularModels, TheoreticalMolecular Probe TechniquesSignal TransductionConnexinsLysine

Identifiers

PMID16490353
PMCPMC7119061
OpenAlexW1981500327

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.