ArticleCell1991
The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3.
Article in Cell, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
97 citing papers in PubMed, 528 citations in OpenAlex.
- Targeted therapies in non-small cell lung cancer: present and future.Faculty reviews · 2023Review
- Cell death in development, maintenance, and diseases of the nervous system.Seminars in immunopathology · 2022Review
- NTRK Fusion in Non-Small Cell Lung Cancer: Diagnosis, Therapy, and TRK Inhibitor Resistance.Frontiers in oncology · 2022Review
- EML4-NTRK3 Fusion Cervical Sarcoma: A Case Report and Literature Review.Frontiers in medicine · 2022Article
- Nerve Growth Factor: A Dual Activator of Noradrenergic and Cholinergic Systems of the Rat Ovary.Frontiers in endocrinology · 2021Article
- Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network.Annals of oncology : official journal of the European Society for Medical Oncology · 2020Review
- Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer.Annals of oncology : official journal of the European Society for Medical Oncology · 2019Review
- TrkA is a binding partner of NPM-ALK that promotes the survival of ALKMolecular oncology · 2017Article
- Exploring Missense Mutations in Tyrosine Kinases Implicated with Neurodegeneration.Molecular neurobiology · 2017Review
- Effect of Estradiol on Neurotrophin Receptors in Basal Forebrain Cholinergic Neurons: Relevance for Alzheimer's Disease.International journal of molecular sciences · 2016Review
- Induction of serpinb1a by PACAP or NGF is required for PC12 cells survival after serum withdrawal.Journal of neurochemistry · 2014Article
- Article
- Loss of neurotrophin-3 from smooth muscle disrupts vagal gastrointestinal afferent signaling and satiation.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- A high cholesterol diet given to apolipoprotein E-knockout mice has a differential effect on the various neurotrophin systems in the hippocampus.Metabolic brain disease · 2011Article
- Gene expression profile in rat dorsal root ganglion following sciatic nerve injury and systemic neurotrophin-3 administration.Journal of molecular neuroscience : MN · 2011Article
- Identification of critical residues within the conserved and specificity patches of nerve growth factor leading to survival or differentiation.The Journal of biological chemistry · 2009Article
- Neurotrophin signaling through tropomyosin receptor kinases contributes to survival and proliferation of non-Hodgkin lymphoma.Experimental hematology · 2009Article
- Role of neurotrophic factors in early ovarian development.Seminars in reproductive medicine · 2009Review
- Astrocyte and neuron intone through glutamate.Neurochemical research · 2008Review
- N-acetylglucosaminyltransferase V modifies TrKA protein, regulates the receptor function.Cellular and molecular neurobiology · 2008Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
The product of the trk proto-oncogene encodes a receptor for nerve growth factor (NGF). Here we show that NGF is a powerful mitogen that can induce resting NIH 3T3 cells to enter S phase, grow in semisolid medium, and become morphologically transformed. These mitogenic effects are absolutely dependent on expression of gp140trk receptors, but do not require the presence of the previously described low affinity NGF receptor. gp140trk also serves as a receptor for the related factor neurotrophin-3 (NT-3), but not for brain-derived neurotrophic factor. Both NGF and NT-3 induce the rapid phosphorylation of gp140trk receptors and the transient expression of c-Fos proteins. However, NT-3 appears to elicit more limited mitogenic responses than NGF. These results indicate that the product of the trk proto-oncogene is sufficient to mediate signal transduction processes induced by NGF and NT-3, at least in proliferating cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.