ArticleWorld journal of gastroenterology2006
Role of Kupffer cells in acute hemorrhagic necrotizing pancreatitis-associated lung injury of rats.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Identification of key genes and signaling pathways associated with acute pancreatitis and acute lung injury by bioinformatics analysis.PloS one · 2026Article
- Gene Regulation of Neutrophils Mediated Liver and Lung Injury through NETosis in Acute Pancreatitis.Inflammation · 2025Article
- Overview of the cellular and immune mechanisms involved in acute pancreatitis: In search of new prognosis biomarkers.Expert reviews in molecular medicine · 2025Review
- From pancreas to lungs: The role of immune cells in severe acute pancreatitis and acute lung injury.Immunity, inflammation and disease · 2024Review
- Da-Huang-Fu-Zi-Tang Ameliorates Severe Acute Pancreatitis by Elevation of M2 Kupffer Cells in Rats.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Pharmacokinetics and pharmacodynamics of Da-Cheng-Qi decoction in the liver of rats with severe acute pancreatitis.World journal of gastroenterology · 2017Article
- HMGB1 and Histones Play a Significant Role in Inducing Systemic Inflammation and Multiple Organ Dysfunctions in Severe Acute Pancreatitis.International journal of inflammation · 2017Review
- The digestive tract as the origin of systemic inflammation.Critical care (London, England) · 2016Review
- Effect of tiron on remote organ injury in rats with severe acute pancreatitis induced by L-arginine.Naunyn-Schmiedeberg's archives of pharmacology · 2016Article
- Inflammation and Edema in the Lung and Kidney of Hemorrhagic Shock Rats Are Alleviated by Biliary Tract External Drainage via the Heme Oxygenase-1 Pathway.Inflammation · 2015Article
- Induction of m2 polarization in primary culture liver macrophages from rats with acute pancreatitis.PloS one · 2014Article
- Taurine attenuates liver injury by downregulating phosphorylated p38 MAPK of Kupffer cells in rats with severe acute pancreatitis.Inflammation · 2012Article
- Role of macrophages in the progression of acute pancreatitis.World journal of gastrointestinal pharmacology and therapeutics · 2010Article
- Essential role of monocytes and macrophages in the progression of acute pancreatitis.World journal of gastroenterology · 2010Review
- Extrapancreatic organ impairment during acute pancreatitis induced by bile-pancreatic duct obstruction. Effect of N-acetylcysteine.International journal of experimental pathology · 2007Article
- Therapeutic effects of caspase-1 inhibitors on acute lung injury in experimental severe acute pancreatitis.World journal of gastroenterology · 2007Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the role of Kupffer cells (KCs) in acute hemorrhagic necrotizing pancreatitis-associated lung injury (AHNP-LI).
methodsForty-two rats were allocated to four groups [sham operation, AHNP model, gadolinium chloride (GdCl3) pretreatment, GdCl3 control]. In GdCl3 pretreatment group, GdCl3 was administered by caudal vein injection 24 h before the AHNP model induction. Blood from the iliac artery, alveolar macrophages and tissues from the pancreas and lung, were collected in six animals per group 3 and 6 h after acute pancreatitis induction. TNF-alpha, IL-1 of serum, myeloperoxidase (MPO) of lung tissue, NF-kappaB activation of alveolar macrophages were detected. Serum AST and ALT in sham operation group and GdCl3 control group were tested. In addition, histopathological changes of the pancreas and lung were observed under light microscope.
resultsMPO of lung tissue and TNF-alpha, IL-1 levels of serum were all reduced significantly in GdCl3 pretreatment group compared to those in AHNP group (P<0.01). NF-kappaB activation of alveolar macrophages was also attenuated significantly in GdCl3 pretreatment group compared to that in AHNP group (P<0.01). The pathological injury of the lung was ameliorated obviously in GdCl3 pretreatment group compared to that in AHNP group. Nevertheless, the serum amylase level did not reduce and injury of the pancreas was not prevented in GdCl3 pretreatment group.
conclusionPulmonary injury induced by AHNP is mediated by KC activation and AHNP-LI can be significantly ameliorated by pretreatment with GdCl3 and KCs play a vital role in AHNP-LI.
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