ArticleBritish journal of cancer1991
Retinoic acid modulates both invasion and plasma membrane ruffling of MCF-7 human mammary carcinoma cells in vitro.
Article in British journal of cancer, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 96 citations in OpenAlex.
- Quantitative Determination of Cellular-and Neurite Motility Speed in Dense Cell Cultures.Frontiers in neuroinformatics · 2019Article
- Chick Heart Invasion Assay for Testing the Invasiveness of Cancer Cells and the Activity of Potentially Anti-invasive Compounds.Journal of visualized experiments : JoVE · 2015Article
- Melatonin: an inhibitor of breast cancer.Endocrine-related cancer · 2015Review
- Spherical cancer models in tumor biology.Neoplasia (New York, N.Y.) · 2015Review
- The bacterial protein azurin impairs invasion and FAK/Src signaling in P-cadherin-overexpressing breast cancer cell models.PloS one · 2013Article
- Article
- Iodothyronine deiodinases and cancer.Journal of endocrinological investigation · 2011Review
- Inhibition of breast cancer cell invasion by melatonin is mediated through regulation of the p38 mitogen-activated protein kinase signaling pathway.Breast cancer research : BCR · 2010Article
- Cell aggregation on agar as an indicator for cell-matrix adhesion: effects of opioids.In vitro cellular & developmental biology. Animal · 2009Article
- Clustering of monosialyl-Gb5 initiates downstream signalling events leading to invasion of MCF-7 breast cancer cells.The Biochemical journal · 2007Article
- Promigratory effect of plasminogen activator inhibitor-1 on invasive breast cancer cell populations.The American journal of pathology · 2002Article
- Low-dose retinoic acid enhances in vitro invasiveness of human oral squamous-cell-carcinoma cell lines.British journal of cancer · 2001Article
- FGF-1 and FGF-2 modulate the E-cadherin/catenin system in pancreatic adenocarcinoma cell lines.British journal of cancer · 2001Article
- Sialylation of E-cadherin does not change the spontaneous or ET-18-OMe-mediated aggregation of MCF-7 human breast cancer cells.Clinical & experimental metastasis · 1999Article
- The alphaE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells.Oncogene · 1999Article
- Effect of MRC-5 fibroblast conditioned medium on breast cancer cell motility and invasion in vitro.Clinical & experimental metastasis · 1998Article
- Multiplex RT-PCR method for the analysis of the expression of human sialyltransferases: application to breast cancer cells.Glycoconjugate journal · 1998Article
- Western immunoblotting and enzymatic activity analysis of cathepsin D in human breast cancer cell lines of different invasive potential. Regulation by 17beta-estradiol, tamoxifen and ICI 182,780.Clinical & experimental metastasis · 1997Article
- Activation of the E-cadherin/catenin complex in human MCF-7 breast cancer cells by all-trans-retinoic acid.British journal of cancer · 1995Article
- Removal of sialic acid from the surface of human MCF-7 mammary cancer cells abolishes E-cadherin-dependent cell-cell adhesion in an aggregation assay.In vitro cellular & developmental biology. Animal · 1995Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The invasiveness of MCF-7 human mammary carcinoma cells was tested in vitro via confronting cultures with embryonic chick heart fragments. Invasive (e.g. MCF-7/6) and non-invasive (e.g. MCF-7/AZ) variants were detected. Automated image analysis of time-lapse video-microscopy recordings showed that the plasma membrane ruffling activity of the invasive MCF-7/6 variant was higher than the ruffling activity of the non-invasive MCF-7/AZ variant. Addition of all-trans-retinoic acid to the culture medium (10(-6) M) inhibited both invasion and ruffling of MCF-7/6 cells, while MCF-7/AZ cells became invasive and acquired an increased ruffling by the same type of treatment. A similar opposite effect on MCF-7 cells was not found after treatment with other ligands of the nuclear steroid/thyroid receptor superfamily. Triiodo-l-thyronine (up to 10(-5) M) and beta-oestradiol (up to 10(-6) M) did not alter the invasiveness of the cells, while dexamethasone (10(-6) M) and the pure anti-oestrogen ICI 164,384 inhibited both invasion and ruffling. Our data show that retinoic acid can modulate invasiveness in opposite directions.
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