ArticleMolecular genetics and genomics : MGG2006
The transcriptional activation region of Msn2p, in Saccharomyces cerevisiae, is regulated by stress but is insensitive to the cAMP signalling pathway.
Article in Molecular genetics and genomics : MGG, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- RkMsn4, a zinc finger transcription factor, regulates carotenoid and lipid metabolism to enhance tolerance to environmental stress inApplied and environmental microbiology · 2026Article
- Identification of a transcription factor AoMsn2 of the Hog1 signaling pathway contributes to fungal growth, development and pathogenicity in Arthrobotrys oligospora.Journal of advanced research · 2025Article
- Light Stress in Yeasts: Signaling and Responses in Creatures of the Night.International journal of molecular sciences · 2023Review
- Response mechanisms of Saccharomyces cerevisiae to the stress factors present in lignocellulose hydrolysate and strategies for constructing robust strains.Biotechnology for biofuels and bioproducts · 2022Review
- Proline Homeostasis inFrontiers in genetics · 2020Review
- Genetic screen of the yeast environmental stress response dynamics uncovers distinct regulatory phases.Molecular systems biology · 2019Article
- Msn2 coordinates a stoichiometric gene expression program.Current biology : CB · 2013Article
- The yeast transcription factor Crz1 is activated by light in a Ca2+/calcineurin-dependent and PKA-independent manner.PloS one · 2013Article
- Molecular characterization of the putative transcription factor SebA involved in virulence in Aspergillus fumigatus.Eukaryotic cell · 2012Article
- Glucose signaling-mediated coordination of cell growth and cell cycle in Saccharomyces cerevisiae.Sensors (Basel, Switzerland) · 2010Review
- Candida glabrata environmental stress response involves Saccharomyces cerevisiae Msn2/4 orthologous transcription factors.Molecular microbiology · 2008Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Msn2p is a transcription factor that mediates a transient cellular response to multiple stresses and to changes in the nutritional environment. It was previously shown that the C-terminal half of Msn2p contains the DNA binding domain, a nuclear localization signal and nuclear export determinants which are activated by stress. In this report, we demonstrate that the N-terminal half of Msn2p contains the transcriptional activation domain(s). In addition, we present evidence that this region of Msn2p is able to mediate both the activation of transcription and export of the protein from the nucleus in response to stress. Interestingly, while the stress response integrated by the components of the C-terminal half that are involved in nucleocytoplasmic localization is reversed by elevated levels of cAMP, the effects of stress on the transcriptional activation domain and the localization determinants present in the N-terminal half of Msn2p are insensitive to variations in the intracellular cAMP concentrations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.