ArticleNaunyn-Schmiedeberg's archives of pharmacology2006
In vivo studies on the effects of alpha1-adrenoceptor antagonists on pupil diameter and urethral tone in rabbits.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 40 citations in OpenAlex.
- The effects of two systemic alpha1-adrenergic blockers on pupil diameter: a prospective randomized single-blind study.Naunyn-Schmiedeberg's archives of pharmacology · 2007Trial
- Effects of Alpha-Lytic Therapy Withdrawal on Choroidal Parameters in Intraoperative Floppy Iris Syndrome High-Risk Patients.Journal of clinical medicine · 2024Article
- Preclinical applications of high-definition manometry system to investigate pelvic floor muscle contribution to continence mechanisms in a rabbit model.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- Evaluation of static and dynamic Pupillometry changes in men using Silodosin for benign prostatic hypertrophy.BMC ophthalmology · 2021Article
- Isoform-specific dynamic translocation of PKC by α1-adrenoceptor stimulation in live cells.Biochemical and biophysical research communications · 2015Article
- The floppy iris syndrome - what urologists and ophthalmologists need to know.Current urology · 2012Review
- Alpha-blockers and intraoperative floppy iris syndrome: ophthalmic adverse events following cataract surgery.Current urology reports · 2010Article
- Management of benign prostatic hyperplasia with silodosin.Open access journal of urology · 2009Review
- Alpha antagonists and intraoperative floppy iris syndrome: A spectrum.Clinical ophthalmology (Auckland, N.Z.) · 2008Article
- Alpha1-adrenoceptor subtypes and lower urinary tract symptoms.International journal of urology : official journal of the Japanese Urological Association · 2008Review
- Medical therapy options for aging men with benign prostatic hyperplasia: focus on alfuzosin 10 mg once daily.Clinical interventions in aging · 2008Review
- [What does "intraoperative floppy iris" syndrome mean for urologists?].Der Urologe. Ausg. A · 2006Article
- Best of the 2006 AUA Annual Meeting: Highlights from the 2006 Annual Meeting of the American Urological Association, May 20-25, 2006, Atlanta, GA.Reviews in urology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alpha1-adrenoceptors mediate contraction of iris dilator smooth muscle and hence pupil dilatation. We compared the ability of i.v. bolus injections of alfuzosin, doxazosin, naftopidil, prazosin, tamsulosin and terazosin to antagonise phenylephrine-induced mydriasis relative to their potency for inhibiting phenylephrine-induced elevations of intraurethral pressure (IUP) in rabbits. Moreover, we compared the ability of these drugs to induce miosis in conscious rabbits in the absence of phenylephrine. All antagonists inhibited the effects of phenylephrine on pupil size and IUP, and the ratio of the respective ED50 values was close to unity in all cases. The doses required to induce statistically significant miosis in the absence of phenylephrine were 30- to 100-fold higher than those inhibiting phenylephrine-induced mydriasis for all antagonists, except for naftopidil. Moreover, the miotic effects of all alpha1-adrenoceptor antagonists were fully reversible within 8 h. We conclude that alfuzosin, doxazosin, naftopidil, prazosin, tamsulosin and terazosin inhibit phenylephrine-induced mydriasis in the same dose range as they inhibit elevations in IUP. Higher doses of all antagonists are required to induce miosis in the absence of an exogenous agonist, and such miosis is always reversible within hours.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.