ArticleGenetics2006
Genotype-by-environment interactions influencing the emergence of rpoS mutations in Escherichia coli populations.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Salmonella stress response systems as targets for anti-virulence strategies.BMC microbiology · 2025Article
- Evolutionary dynamics and structural consequences of de novo beneficial mutations and mutant lineages arising in a constant environment.BMC biology · 2021Article
- Experimental Evolution of Anticipatory Regulation inFrontiers in microbiology · 2021Article
- High mutation rates limit evolutionary adaptation in Escherichia coli.PLoS genetics · 2018Article
- Metabolic constraints on the evolution of antibiotic resistance.Molecular systems biology · 2017Article
- Article
- The General Stress Response Is Conserved in Long-Term Soil-Persistent Strains of Escherichia coli.Applied and environmental microbiology · 2016Article
- Blue-Light Inhibition of Listeria monocytogenes Growth Is Mediated by Reactive Oxygen Species and Is Influenced by σB and the Blue-Light Sensor Lmo0799.Applied and environmental microbiology · 2016Article
- Continuous evolution of laboratory strains of bacteria and yeast.Journal of biosciences · 2014Article
- Article
- A design-constraint trade-off underpins the diversity in ecologically important traits in species Escherichia coli.The ISME journal · 2013Article
- Multiple Pathways of Genome Plasticity Leading to Development of Antibiotic Resistance.Antibiotics (Basel, Switzerland) · 2013Review
- Tangled bank of experimentally evolved Burkholderia biofilms reflects selection during chronic infections.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The basis of antagonistic pleiotropy in hfq mutations that have opposite effects on fitness at slow and fast growth rates.Heredity · 2013Article
- Effect of the Bacillus atrophaeus subsp. globigii Spo0F H101R mutation on strain fitness.Applied and environmental microbiology · 2012Article
- Escherichia coli lacking RpoS are rare in natural populations of non-pathogens.G3 (Bethesda, Md.) · 2012Article
- Phenotypic diversity caused by differential RpoS activity among environmental Escherichia coli isolates.Applied and environmental microbiology · 2011Article
- The renaissance of continuous culture in the post-genomics age.Journal of industrial microbiology & biotechnology · 2010Article
- Genomic identification of a novel mutation in hfq that provides multiple benefits in evolving glucose-limited populations of Escherichia coli.Journal of bacteriology · 2010Article
- Evolution of the RpoS regulon: origin of RpoS and the conservation of RpoS-dependent regulation in bacteria.Journal of molecular evolution · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polymorphisms in rpoS are common in Escherichia coli. rpoS status influences a trade-off between nutrition and stress resistance and hence fitness across different environments. To analyze the selective pressures acting on rpoS, measurement of glucose transport rates in rpoS+ and rpoS bacteria was used to estimate the role of F(nc), the fitness gain due to improved nutrient uptake, in the emergence of rpoS mutations in nutrient-limited chemostat cultures. Chemostats with set atmospheres, temperatures, pH's, antibiotics, and levels of osmotic stress were followed. F(nc) was reduced under anaerobiosis, high osmolarity, and with chloramphenicol, consistent with a reduced rate of rpoS enrichment in these conditions. F(nc) remained high, however, with alkaline pH and low temperature but rpoS sweeps were diminished. Under these conditions, F(sp), the fitness reduction due to lowered stress protection, became significant. We also estimated whether the fitness need for the gene was related to its regulation. No consistent pattern emerged between the level of RpoS and the loss of rpoS function in particular environments. This dissection allows an unprecedented view of the genotype-by-environment interactions controlling a mutational sweep and shows that both F(nc) and F(sp) are influenced by individual stresses and that additional factors contribute to selection pressure in some environments.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.