ArticleGenetics2006
High-resolution quantitative trait locus mapping reveals sign epistasis controlling ovariole number between two Drosophila species.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Evolution of Size-Fecundity Relationship in Medaka Fish From Different Latitudes.Molecular ecology · 2024Article
- A new hybrid incompatibility locus between Drosophila melanogaster and Drosophila sechellia.Genetics · 2024Article
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- Societies to genes: can we get there from here?Genetics · 2021Article
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- Quantifying the extent of morphological homoplasy: A phylogenetic analysis of 490 characters inEvolution letters · 2019Article
- Coadapted genomes and selection on hybrids: Fisher's geometric model explains a variety of empirical patterns.Evolution letters · 2018Article
- The Genetic Architecture of Ovariole Number inG3 (Bethesda, Md.) · 2017Article
- Genetic and Transgenic Reagents forG3 (Bethesda, Md.) · 2017Article
- Drosophila yakuba mayottensis, a new model for the study of incipient ecological speciation.Fly · 2017Article
- The Hippo pathway regulates homeostatic growth of stem cell niche precursors in the Drosophila ovary.PLoS genetics · 2015Article
- Insulin signalling underlies both plasticity and divergence of a reproductive trait in Drosophila.Proceedings. Biological sciences · 2014Article
- Evolution of multiple additive loci caused divergence between Drosophila yakuba and D. santomea in wing rowing during male courtship.PloS one · 2012Article
- Automated tracking of animal posture and movement during exploration and sensory orientation behaviors.PloS one · 2012Article
- Genetic basis for developmental homeostasis of germline stem cell niche number: a network of Tramtrack-Group nuclear BTB factors.PloS one · 2012Article
- Heterozygosity and its unexpected correlations with hybrid sterility.Evolution; international journal of organic evolution · 2011Article
- Evolution and inheritance of early embryonic patterning in Drosophila simulans and D. sechellia.Evolution; international journal of organic evolution · 2011Article
- Article
- Support for the reproductive ground plan hypothesis of social evolution and major QTL for ovary traits of Africanized worker honey bees (Apis mellifera L.).BMC evolutionary biology · 2011Article
- Article
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3 authors.
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Abstract
Identifying the genes underlying genetically complex traits is of fundamental importance for medicine, agriculture, and evolutionary biology. However, the level of resolution offered by traditional quantitative trait locus (QTL) mapping is usually coarse. We analyze here a trait closely related to fitness, ovariole number. Our initial interspecific mapping between Drosophila sechellia (8 ovarioles/ovary) and D. simulans (15 ovarioles/ovary) identified a major QTL on chromosome 3 and a minor QTL on chromosome 2. To refine the position of the major QTL, we selected 1038 additional recombinants in the region of interest using flanking morphological markers (selective phenotyping). This effort generated approximately one recombination event per gene and increased the mapping resolution by approximately seven times. Our study thus shows that using visible markers to select for recombinants can efficiently increase the resolution of QTL mapping. We resolved the major QTL into two epistatic QTL, QTL3a and QTL3b. QTL3a shows sign epistasis: it has opposite effects in two different genetic backgrounds, the presence vs. the absence of the QTL3b D. sechellia allele. This property of QTL3a allows us to reconstruct the probable order of fixation of the QTL alleles during evolution.
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