ArticleGenetics2006
Schizosaccharomyces pombe Git1 is a C2-domain protein required for glucose activation of adenylate cyclase.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- CaBMC biology · 2025Article
- Use of a Fission Yeast Platform to Identify and Characterize Small Molecule PDE Inhibitors.Frontiers in pharmacology · 2021Review
- Roles of the fission yeast UNC-13/Munc13 protein Ync13 in late stages of cytokinesis.Molecular biology of the cell · 2018Article
- A Genetic Screen for Fission Yeast Gene Deletion Mutants Exhibiting Hypersensitivity to Latrunculin A.G3 (Bethesda, Md.) · 2016Article
- Dissection of the PHO pathway in Schizosaccharomyces pombe using epistasis and the alternate repressor adenine.Current genetics · 2015Article
- Multistep regulation of protein kinase A in its localization, phosphorylation and binding with a regulatory subunit in fission yeast.Current genetics · 2011Article
- A fission yeast-based platform for phosphodiesterase inhibitor HTSs and analyses of phosphodiesterase activity.Handbook of experimental pharmacology · 2011Review
- Cellular stress induces cytoplasmic RNA granules in fission yeast.RNA (New York, N.Y.) · 2011Article
- Remote homology between Munc13 MUN domain and vesicle tethering complexes.Journal of molecular biology · 2009Article
- Early development of Moniliophthora perniciosa basidiomata and developmentally regulated genes.BMC microbiology · 2009Article
- Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Schizosaccharomyces pombe senses environmental glucose through a cAMP-signaling pathway, activating cAMP-dependent protein kinase A (PKA). This requires nine git (glucose insensitive transcription) genes that encode adenylate cyclase, the PKA catalytic subunit, and seven "upstream" proteins required for glucose-triggered adenylate cyclase activation, including three heterotrimeric G-protein subunits and its associated receptor. We describe here the cloning and characterization of the git1+ gene. Git1 is distantly related to a small group of uncharacterized fungal proteins, including a second S. pombe protein that is not functionally redundant with Git1, as well as to members of the UNC-13/Munc13 protein family. Mutations in git1+ demonstrate functional roles for the two most highly conserved regions of the protein, the C2 domain and the MHD2 Munc homology domain. Cells lacking Git1 are viable, but display phenotypes associated with cAMP-signaling defects, even in strains expressing a mutationally activated G alpha-subunit, which activates adenylate cyclase. These cells possess reduced basal cAMP levels and fail to mount a cAMP response to glucose. In addition, Git1 and adenylate cyclase physically interact and partially colocalize in the cell. Thus, Git1 is a critical component of the S. pombe glucose/cAMP pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.