ArticleCancer research2006
Endocytic recycling compartments altered in cisplatin-resistant cancer cells.
Article in Cancer research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- Article
- Autophagy modulating agents as chemosensitizers for cisplatin therapy in cancer.Investigational new drugs · 2021Review
- Tumor-intrinsic and -extrinsic (immune) gene signatures robustly predict overall survival and treatment response in high grade serous ovarian cancer patients.American journal of cancer research · 2021Article
- Cancer stem cells and their niche in the progression of squamous cell carcinoma.Cancer science · 2020Review
- Chemotherapy-induced apoptosis, autophagy and cell cycle arrest are key drivers of synergy in chemo-immunotherapy of epithelial ovarian cancer.Cancer immunology, immunotherapy : CII · 2018Article
- Suppression of chloride voltage-gated channel 3 expression increases sensitivity of human glioma U251 cells to cisplatin through lysosomal dysfunction.Oncology letters · 2018Article
- Evaluation of fluorophore-tethered platinum complexes to monitor the fate of cisplatin analogs.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2015Article
- Reduced Intracellular Drug Accumulation in Drug-Resistant Leukemia Cells is Not Only Solely Due to MDR-Mediated Efflux but also to Decreased Uptake.Frontiers in oncology · 2014Article
- Biophysics of cell membrane lipids in cancer drug resistance: Implications for drug transport and drug delivery with nanoparticles.Advanced drug delivery reviews · 2013Review
- Cisplatin resistance: a cellular self-defense mechanism resulting from multiple epigenetic and genetic changes.Pharmacological reviews · 2012Review
- Developing central nervous system and vulnerability to platinum compounds.Chemotherapy research and practice · 2011Article
- Copper transporter 2 regulates endocytosis and controls tumor growth and sensitivity to cisplatin in vivo.Molecular pharmacology · 2011Article
- Role of the RNA-binding protein IMP-2 in muscle cell motility.Molecular and cellular biology · 2010Article
- Extensive disease small cell lung cancer dose-response relationships: implications for resistance mechanisms.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2010Article
- Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Cisplatin interaction with phosphatidylserine bilayer studied by solid-state NMR spectroscopy.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2010Article
- Involvement of vacuolar sequestration and active transport in tolerance of Saccharomyces cerevisiae to hop iso-alpha-acids.Applied and environmental microbiology · 2010Article
- Fractal analysis and ionic dependence of endocytotic membrane activity of human breast cancer cells.European biophysics journal : EBJ · 2009Article
- SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism.Molecular cancer research : MCR · 2008Article
- The chemical genomic portrait of yeast: uncovering a phenotype for all genes.Science (New York, N.Y.) · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The clinical utility of cisplatin to treat human malignancies is often limited by the development of drug resistance. We have previously shown that cisplatin-resistant human KB adenocarcinoma cells that are cross-resistant to methotrexate and heavy metals have altered endocytic recycling. In this work, we tracked lipids in the endocytic recycling compartment (ERC) and found that the distribution of the ERC is altered in KB-CP.5 cells compared with parental KB-3-1 cells. A tightly clustered ERC is located near the nucleus in parental KB-3-1 cells but it appears loosely arranged and widely dispersed throughout the cytoplasm in KB-CP.5 cells. The altered distribution of the ERC in KB-CP.5 cells is related to the amount and distribution of stable detyrosinated microtubules (Glu-alpha-tubulin), as previously shown in Chinese hamster ovary B104-5 cells that carry a temperature-sensitive Glu-alpha-tubulin allele. In addition, B104-5 cells with a dispersed ERC under nonpermissive conditions were more resistant to cisplatin compared with B104-5 cells with a clustered ERC under permissive conditions. We conclude that resistance to cisplatin might be due, in part, to reduced uptake of cisplatin resulting from an endocytic defect reflecting defective formation of the ERC, possibly related to a shift in the relative amounts and distributions of stable microtubules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.