ArticleThe British journal of ophthalmology2006
Expression of insulin-like growth factor binding protein-3 in pterygium tissue.
Article in The British journal of ophthalmology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Exploring dysregulation of cuproptosis-related genes molecular clusters and candidate biomarkers in pterygium.Scientific reports · 2026Article
- Investigating immune cell infiltration and gene expression features in pterygium pathogenesis.Scientific reports · 2025Article
- Identification of biomarkers and immune microenvironment associated with pterygium through bioinformatics and machine learning.Frontiers in molecular biosciences · 2024Article
- Key Genes of Immunity Associated with Pterygium and Primary Sjögren's Syndrome.International journal of molecular sciences · 2023Article
- Cell atlas of the human ocular anterior segment: Tissue-specific and shared cell types.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Changes of Corneal Biomechanical Properties upon Exclusive Ytt-/Sr-90 Irradiation of Pterygium.Sensors (Basel, Switzerland) · 2021Article
- Comprehensive Analysis of the Transcriptome-Wide m6A Methylome in Pterygium by MeRIP Sequencing.Frontiers in cell and developmental biology · 2021Article
- Identification of Functional Genes in Pterygium Based on Bioinformatics Analysis.BioMed research international · 2020Article
- Article
- Identification of pathogenic genes of pterygium based on the Gene Expression Omnibus database.International journal of ophthalmology · 2019Article
- Identification and Interaction Analysis of Significant Genes and MicroRNAs in Pterygium.BioMed research international · 2019Article
- Identification of pterygium-related mRNA expression profiling by microarray analysis.Eye (London, England) · 2017Article
- Biomechanical Modeling of Pterygium Radiation Surgery: A Retrospective Case Study.Sensors (Basel, Switzerland) · 2017Article
- Aberrant expression of genes and proteins in pterygium and their implications in the pathogenesis.International journal of ophthalmology · 2017Review
- MicroRNA-215 Regulates Fibroblast Function: Insights from a Human Fibrotic Disease.Cell cycle (Georgetown, Tex.) · 2015Article
- Article
- Relationship of agr expression and function with virulence and vancomycin treatment outcomes in experimental endocarditis due to methicillin-resistant Staphylococcus aureus.Antimicrobial agents and chemotherapy · 2011Article
- Distinct gene subsets in pterygia formation and recurrence: dissecting complex biological phenomenon using genome wide expression data.BMC medical genomics · 2009Article
- Comparison of gene expression profiles of conjunctival cell lines with primary cultured conjunctival epithelial cells and human conjunctival tissue.Gene expression · 2009Article
- Calcium-binding S100 protein expression in pterygium.Molecular vision · 2009Article
Corrections and comments
- Commented on byPterygium.2006
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPterygium is a fibrovascular overgrowth from the conjunctiva onto the cornea. The pathogenesis of this common ocular surface disorder is not well understood and the only treatment is surgical removal.
methodsDNA microarray analysis of primary pterygium tissue was carried out using uninvolved conjunctiva tissue as a comparison for gene expression levels. Real time polymerase chain reaction (PCR) was used to verify the mRNA level of expression for genes changed in pterygium. Western blot analysis and immunohistochemistry showed protein expression levels and the tissue distribution.
resultsMicroarray analysis revealed that mRNA levels of a number of genes were changed in primary pterygium. In particular the gene for insulin-like growth factor binding protein-3, (IGFBP3), which modulates the effects of insulin-like growth factor on cells was significantly decreased. Both the message and protein expression of IGFBP3 in pterygium were decreased compared to normal, uninvolved conjunctiva.
conclusionDecreased levels of IGFBP3 protein have been strongly correlated with the presence of cancer. Identification of the low level of expression of IGFBP3 in pterygium suggests that the pathway controlling cell proliferation has lost an important control mechanism, which may explain the continued growth of pterygium.
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