ReviewBrain research2006
Conditional and inducible gene recombineering in the mouse inner ear.
Review in Brain research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Uncovering the fine print of the CreERT2-LoxP system while generating a conditional knockout mouse model of Ssrp1 gene.PloS one · 2018Article
- MouseFrontiers in molecular neuroscience · 2017Article
- Conditional gene manipulation: Cre-ating a new biological era.Journal of Zhejiang University. Science. B · 2012Review
- Conditional gene expression in the mouse inner ear using Cre-loxP.Journal of the Association for Research in Otolaryngology : JARO · 2012Review
- Outer hair cell-specific prestin-CreERT2 knockin mouse lines.Genesis (New York, N.Y. : 2000) · 2012Article
- Methods of cell purification: a critical juncture for laboratory research and translational science.Cells, tissues, organs · 2012Article
- The role of glucocorticoids for spiral ganglion neuron survival.Brain research · 2009Review
- Regenerating cochlear hair cells: quo vadis stem cell.Cell and tissue research · 2008Review
- Stem cells and molecular strategies to restore hearing.Panminerva medica · 2008Review
- Barhl1 regulatory sequences required for cell-specific gene expression and autoregulation in the inner ear and central nervous system.Molecular and cellular biology · 2008Article
- Auditory transduction in the mouse.Pflugers Archiv : European journal of physiology · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Genetically engineered mice have greatly improved our understanding of gene functions and disease mechanisms. Nevertheless, the traditional knock-out approach has limitations in the overall viability of mutants. The application of the Cre/loxP system in the inner ear can help bypass this difficulty by generation of conditional gene recombineering. However, to do so requires an expression system that allows ear-specific temporally inducible, gene abrogation of one or more of the increasingly available floxed genes. To date, three approaches have been successfully used to create murine inner ear-specific Cre lines: conventional transgenesis, BAC transgenesis, and gene knock-in. Unfortunately, timing of conditional Cre activity does not extend beyond the regulatory range of the gene controlling Cre expression. Rectification of this problem requires the generation of tamoxifen or tetracycline inducible systems in the inner ear. Examination of integrase expression at different loci will facilitate studies on the expression of exogenous transgenes. These genetic applications for the mouse genome will dramatically advance in vivo gene function studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.