ArticleClinical and experimental immunology2006
CD127 expression and regulation are altered in the memory CD8 T cells of HIV-infected patients--reversal by highly active anti-retroviral therapy (HAART).
Article in Clinical and experimental immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 74 citations in OpenAlex.
- Multifunctional T-cell characteristics induced by a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine regimen given to healthy adults are dependent on the route and dose of administration.Journal of virology · 2008Trial
- Alterations in high-dimensional T-cell profile and gene signature of immune aging in HIV-infected older adults without viremia.Aging cell · 2022Article
- HIV-1 infection and the lack of viral control are associated with greater expression of interleukin-21 receptor on CD8+ T cells.AIDS (London, England) · 2021Article
- IL-7 induces sCD127 release and mCD127 downregulation in human CD8European journal of immunology · 2020Article
- Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8Frontiers in immunology · 2017Review
- Transcriptional regulation of the IL-7Rα gene by dexamethasone and IL-7 in primary human CD8 T cells.Immunogenetics · 2017Article
- American tegumentary leishmaniasis: T-cell differentiation profile of cutaneous and mucosal forms-co-infection with Trypanosoma cruzi.Medical microbiology and immunology · 2016Article
- Generalized Liver- and Blood-Derived CD8+ T-Cell Impairment in Response to Cytokines in Chronic Hepatitis C Virus Infection.PloS one · 2016Article
- IL-7 receptor recovery on CD8 T-cells isolated from HIV+ patients is inhibited by the HIV Tat protein.PloS one · 2014Article
- Expression of the IL-7 receptor alpha-chain is down regulated on the surface of CD4 T-cells by the HIV-1 Tat protein.PloS one · 2014Article
- HIV immune activation drives increased Eomes expression in memory CD8 T cells in association with transcriptional downregulation of CD127.AIDS (London, England) · 2013Article
- Association between peripheral T-Lymphocyte activation and impaired bone mineral density in HIV-infected patients.Journal of translational medicine · 2013Article
- T-Cell Signaling in HIV-1 Infection.The open virology journal · 2013Article
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- Pegylated interferon α enhances recovery of memory T cells in e antigen positive chronic hepatitis B patients.Virology journal · 2012Article
- Effects of combined antiretroviral therapy on B- and T-cell release from production sites in long-term treated HIV-1+ patients.Journal of translational medicine · 2012Article
- In vitro HIV Type 1 infection indirectly alters CD127 expression on CD8(+) T cells.AIDS research and human retroviruses · 2012Article
- Loss of CD127 & increased immunosenescence of T cell subsets in HIV infected individuals.The Indian journal of medical research · 2011Article
- HIV infection of thymocytes inhibits IL-7 activity without altering CD127 expression.Retrovirology · 2011Article
- Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HIV infection activates abnormally the immune system and the chronic phase is accompanied by marked alterations in the CD8 compartment. The expression of CD127 (IL-7R alpha chain) by memory CD8 T lymphocytes in HIV-infected patients is analysed and reported. The memory CD8 T cell subset was characterized by expression of CD45RA and CD27 markers, and CD127 cell surface expression was measured ex vivo by four-colour flow cytometry. HIV infection was associated with a fall in the proportion of CD127(+) cells among memory CD8 lymphocytes that resulted in a higher CD127(-) CD45RA(-)CD27(+) CD8 T cell count in HIV-infected patients. Diminished CD127 cell surface expression [mean fluorescence intensity (MFI)] by positive cells was also observed in this subset. The data suggest that these defects were reversed by highly active anti-retroviral therapy (HAART). The regulation of CD127 expression was also studied in vitro. Down-regulation of CD127 by interleukin (IL)-7 was observed in memory CD8 lymphocytes from healthy donors and HAART patients. Expression of CD127 by memory CD8 lymphocytes cultured in the absence of IL-7 confirmed that IL-7R regulation is altered in viraemic patients. Under the same experimental conditions, memory CD8 lymphocytes from HAART patients were shown to express CD127 at levels comparable to cells from healthy individuals. Altered CD127 cell surface expression and defective CD127 regulation in the memory CD8 T lymphocytes of HIV-infected patients are potential mechanisms by which these cells may be impeded in their physiological response to endogenous IL-7 stimulatory signals. Our data suggest that these defects are reversed during the immune reconstitution that follows HAART.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.