ReviewEmerging infectious diseases2005
Human granulocytic anaplasmosis and Anaplasma phagocytophilum.
Review in Emerging infectious diseases, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 217 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
217 citing papers in PubMed, 1 synthesis or guideline pooled it, 473 citations in OpenAlex.
- Human pathogens associated with the blacklegged tick Ixodes scapularis: a systematic review.Parasites & vectors · 2016Pooled it
- Trial
- Molecular Detection of Anaplasma spp. in Horses From Golestan Province, Northern Iran.Veterinary medicine and science · 2026Article
- Human granulocytic anaplasmosis in Poland: clinical déjà vu or a new chapter in tick-borne diseases?IJID regions · 2026Article
- Powassan Virus in the United States: An AI-Integrative One Health Scoping Review of Ecological Drivers, Zoonotic Interactions, Symptom Profiles, and Public Health Implications.Infectious disease reports · 2026Review
- Are there other undiagnosed tick-borne infections in children being evaluated for Lyme neuroborreliosis?BMC pediatrics · 2026Article
- An in-house nucleic acid test for detection of Anaplasma phagocytophilum in whole blood donor samples.Transfusion · 2026Article
- Metagenomic surveillance of tick-borne pathogens and microbiomes in Huntingdon County, Pennsylvania.One health (Amsterdam, Netherlands) · 2026Article
- First detection ofFrontiers in veterinary science · 2026Article
- Severe Thrombocytopenia and New Right Bundle Branch Block in Human Granulocytic Anaplasmosis: A Case Report.Journal of Brown hospital medicine · 2026Article
- Article
- Exploration of geographical population structure ofCurrent research in parasitology & vector-borne diseases · 2026Article
- High diversity and distribution of ticks and tick-borne diseases in Sudan emphasizes the need for implementing cost-effective community One Health strategy.Frontiers in microbiology · 2026Review
- Molecular detection of tick-borne pathogens in cattle ticks from the Lao People's Democratic Republic.Parasites & vectors · 2025Article
- Molecular detection and characterization ofInternational journal for parasitology. Parasites and wildlife · 2025Article
- An arthropod transporter IsOATP4056 exerts inhibitory effect on its interacting membrane protein to facilitate rickettsial pathogen survival in ticks.Cell communication and signaling : CCS · 2025Article
- Molecular Detection and Phylogenetic Analysis ofMicroorganisms · 2025Article
- Tick-Borne Pathogens in Companion Animals and Zoonotic Risk in Portugal: A One Health Surveillance Approach.Microorganisms · 2025Article
- Impact of Human Granulocytic Anaplasmosis in Spain from 1997 to 2022.Tropical medicine and infectious disease · 2025Review
- Comparative Analysis of Bacterial Tick-Borne Pathogens in Questing Ticks from Sambia Peninsula, Kaliningrad Oblast, Russia: Spring and Autumn Prevalence and Public Health Risks.Microorganisms · 2025Article
157 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Human granulocytic anaplasmosis is a tickborne rickettsial infection of neutrophils caused by Anaplasma phagocytophilum. The human disease was first identified in 1990, although the pathogen was defined as a veterinary agent in 1932. Since 1990, US cases have markedly increased, and infections are now recognized in Europe. A high international seroprevalence suggests infection is widespread but unrecognized. The niche for A. phagocytophilum, the neutrophil, indicates that the pathogen has unique adaptations and pathogenetic mechanisms. Intensive study has demonstrated interactions with host-cell signal transduction and possibly eukaryotic transcription. This interaction leads to permutations of neutrophil function and could permit immunopathologic changes, severe disease, and opportunistic infections. More study is needed to define the immunology and pathogenetic mechanisms and to understand why severe disease develops in some persons and why some animals become long-term permissive reservoir hosts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.