ArticleJournal of neurology, neurosurgery, and psychiatry2006
Thrombolysis for acute stroke with special emphasis on the very old: experience from a single Dutch centre.
Article in Journal of neurology, neurosurgery, and psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- [European Stroke Organisation 2008 guidelines for managing acute cerebral infarction or transient ischemic attack : part 2].Der Nervenarzt · 2008Guideline
- Stroke in Frail Older People.Geriatrics (Basel, Switzerland) · 2017Article
- Absolute and Relative Contraindications to IV rt-PA for Acute Ischemic Stroke.The Neurohospitalist · 2015Review
- Article
- Current perspectives on the use of intravenous recombinant tissue plasminogen activator (tPA) for treatment of acute ischemic stroke.Vascular health and risk management · 2014Review
- Prestroke dementia is associated with poor outcomes after reperfusion therapy among elderly stroke patients.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2013Article
- Contraindications to intravenous rtPA for acute stroke: A critical reappraisal.Neurology. Clinical practice · 2013Article
- Safety and efficacy of thrombolysis with intravenous alteplase in older stroke patients.Drugs & aging · 2013Review
- Article
- Safety of thrombolysis in patients over the age of 80.The neurologist · 2012Article
- Navigating the gray zones of stroke management for a graying population.Cerebrovascular diseases (Basel, Switzerland) · 2010Article
- Thrombolysis, stroke-unit admission and early rehabilitation in elderly patients.Nature reviews. Neurology · 2009Review
- Intra-arterial recanalization techniques for patients 80 years or older with acute ischemic stroke: pooled analysis from 4 prospective studies.AJNR. American journal of neuroradiology · 2009Article
- Outcomes of intravenous tissue plasminogen activator for acute ischemic stroke in patients aged 90 years or older.Mayo Clinic proceedings · 2009Article
- [Ischemic stroke in the elderly--analysis of the Austrian Stroke Unit Registry].Wiener medizinische Wochenschrift (1946) · 2008Article
- Acute ischaemic stroke in patients aged 80 years and older: focus on the tolerability of thrombolytic agents.Drugs & aging · 2008Review
- Thrombolytic therapy for acute ischaemic stroke in octogenarians: selection by magnetic resonance imaging improves safety but does not improve outcome.Journal of neurology, neurosurgery, and psychiatry · 2007Article
- Lack of experience of intravenous thrombolysis for acute ischaemic stroke does not influence the proportion of patients treated.Emergency medicine journal : EMJ · 2007Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to describe the clinical experience in 184 consecutive stroke patients first-ever treated with recombinant tissue plasminogen activator (rt-PA) at a single Dutch centre, with special emphasis on results among the very old. Outcome parameters were the modified Rankin scale (mRs) at 3 months and symptomatic intracranial haemorrhage (SICH). Outcome was related to age. A total of 184 patients were treated of whom 45 were 80 years of age or older (24%). Sixty two (45%) of 139 patients < 80 years of age and 12 (27%) of 45 patients > or = 80 years of age had a favourable outcome defined as an mRs score of 0 or 1 (OR 2.21; 95% CI: 1.06 to 4.46). There was a good outcome (mRs score < or = 2) in 88 (63%) and 16 (36%) patients, respectively (OR 3.13; 95% CI: 1.55 to 6.30). SICH was observed in four of 139 (2.9%) patients < 80 years of age and in five of 45 (11.1%) patients > or = 80 years of age (OR 4.22; 95% CI: 1.08 to 16.46). The results of this study underline the uncertainty regarding the risk/benefit ratio of rt-PA treatment in acute stroke in patients over 80 years of age.
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