ArticleThe Journal of physiology2006
Reflex activation of rat fusimotor neurons by body surface cooling, and its dependence on the medullary raphe.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 71 citations in OpenAlex.
- A hypothalamomedullary network for physiological responses to environmental stresses.Nature reviews. Neuroscience · 2022Review
- Physiological and Behavioral Mechanisms of Thermoregulation in Mammals.Animals : an open access journal from MDPI · 2021Review
- The Role of Thermosensitive Ion Channels in Mammalian Thermoregulation.Advances in experimental medicine and biology · 2021Article
- Neurons in the rat ventral lateral preoptic area are essential for the warm-evoked inhibition of brown adipose tissue and shivering thermogenesis.Acta physiologica (Oxford, England) · 2019Article
- Central nervous system circuits that control body temperature.Neuroscience letters · 2019Review
- Review
- Different Effects of Cold Stimulation on Reflex and Non-Reflex Components of Poststroke Spastic Hypertonia.Frontiers in neurology · 2017Article
- Central neural control of thermoregulation and brown adipose tissue.Autonomic neuroscience : basic & clinical · 2016Review
- Central control of body temperature.F1000Research · 2016Review
- Contributions of white and brown adipose tissues and skeletal muscles to acute cold-induced metabolic responses in healthy men.The Journal of physiology · 2015Article
- Skin temperature: its role in thermoregulation.Acta physiologica (Oxford, England) · 2014Review
- Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Swim stress activates serotonergic and nonserotonergic neurons in specific subdivisions of the rat dorsal raphe nucleus in a temperature-dependent manner.Neuroscience · 2011Article
- 2010 Carl Ludwig Distinguished Lectureship of the APS Neural Control and Autonomic Regulation Section: Central neural pathways for thermoregulatory cold defense.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Article
- Central neural pathways for thermoregulation.Frontiers in bioscience (Landmark edition) · 2011Review
- Cellular bioenergetics as a target for obesity therapy.Nature reviews. Drug discovery · 2010Review
- Multiple thermoregulatory effectors with independent central controls.European journal of applied physiology · 2010Review
- Short of air? Cool it!The Journal of physiology · 2009Article
- Control of cardiac rate, contractility, and atrioventricular conduction by medullary raphe neurons in anesthetized rats.American journal of physiology. Heart and circulatory physiology · 2009Article
- Central control of thermogenesis in mammals.Experimental physiology · 2008Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nature of muscle efferent fibre activation during whole body cooling was investigated in urethane-anaesthetized rats. Multiunit efferent activity to the gastrocnemius muscle was detected when the trunk skin was cooled by a water-perfused jacket to below 36.0 +/- 0.7 degrees C. That efferent activity was not blocked by hexamethonium (50 mg kg(-1), i.v.) and was not associated with movement or electromyographic activity. Cold-induced efferent activity enhanced the discharge of afferent filaments from the isotonically stretched gastrocnemius muscle, demonstrating that it was fusimotor. Fusimotor neurons were activated by falls in trunk skin temperature, but that activity ceased when the skin was rewarmed, regardless of how low core temperature had fallen. While low core temperature alone was ineffective, a high core temperature could inhibit the fusimotor response to skin cooling. Fusimotor activation by skin cooling was often accompanied by desynchronization of the frontal electroencephalogram (EEG), but was not a simple consequence of cortical arousal, in that warming the scrotum desynchronized the EEG without activating fusimotor fibres. Inhibition of neurons in the rostral medullary raphé by microinjections of glycine (0.5 m, 120-180 nl) reduced the fusimotor response to skin cooling by 95 +/- 3%, but did not prevent the EEG response. These results are interpreted as showing a novel thermoregulatory reflex that is triggered by cold exposure. It may underlie the increased muscle tone that precedes overt shivering, and could also serve to amplify shivering. Like several other cold-defence responses, this reflex depends upon neurons in the rostral medullary raphé.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.