ArticleJournal of bacteriology2006
Trapping of a spiral-like intermediate of the bacterial cytokinetic protein FtsZ.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Connecting sequence features within the disordered C-terminal linker ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Molecular Evolution of Tubulins in Diatoms.International journal of molecular sciences · 2022Article
- The bacterial divisome: ready for its close-up.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- A mutation in Escherichia coli ftsZ bypasses the requirement for the essential division gene zipA and confers resistance to FtsZ assembly inhibitors by stabilizing protofilament bundling.Molecular microbiology · 2015Article
- Bacterial Filament Systems: Toward Understanding Their Emergent Behavior and Cellular Functions.The Journal of biological chemistry · 2015Review
- Article
- FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one.Microbiology and molecular biology reviews : MMBR · 2010Review
- In vivo structure of the E. coli FtsZ-ring revealed by photoactivated localization microscopy (PALM).PloS one · 2010Article
- Cellular polarity in prokaryotic organisms.Cold Spring Harbor perspectives in biology · 2009Review
- Simple modeling of FtsZ polymers on flat and curved surfaces: correlation with experimental in vitro observations.PMC biophysics · 2009Article
- The dynamic nature of the bacterial cytoskeleton.Cellular and molecular life sciences : CMLS · 2009Review
- Bacterial cell division: assembly, maintenance and disassembly of the Z ring.Nature reviews. Microbiology · 2009Review
- Modeling the physics of FtsZ assembly and force generation.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- In Escherichia coli, MreB and FtsZ direct the synthesis of lateral cell wall via independent pathways that require PBP 2.Journal of bacteriology · 2009Article
- Functional identification of HugZ, a heme oxygenase from Helicobacter pylori.BMC microbiology · 2008Article
- The bacterial cell division protein FtsZ assembles into cytoplasmic rings in fission yeast.Genes & development · 2008Article
- The bacterial cytoskeleton.Microbiology and molecular biology reviews : MMBR · 2006Review
- Cell Cycle Machinery in Bacillus subtilis.Sub-cellular biochemistryReview
- FtsZ Constriction Force - Curved Protofilaments Bending Membranes.Sub-cellular biochemistryArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The earliest stage in bacterial cell division is the formation of a ring, composed of the tubulin-like protein FtsZ, at the division site. Tight spatial and temporal regulation of Z-ring formation is required to ensure that division occurs precisely at midcell between two replicated chromosomes. However, the mechanism of Z-ring formation and its regulation in vivo remain unresolved. Here we identify the defect of an interesting temperature-sensitive ftsZ mutant (ts1) of Bacillus subtilis. At the nonpermissive temperature, the mutant protein, FtsZ(Ts1), assembles into spiral-like structures between chromosomes. When shifted back down to the permissive temperature, functional Z rings form and division resumes. Our observations support a model in which Z-ring formation at the division site arises from reorganization of a long cytoskeletal spiral form of FtsZ and suggest that the FtsZ(Ts1) protein is captured as a shorter spiral-forming intermediate that is unable to complete this reorganization step. The ts1 mutant is likely to be very valuable in revealing how FtsZ assembles into a ring and how this occurs precisely at the division site.
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