ArticleBMC neuroscience2006
Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus.
Article in BMC neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
39 citing papers in PubMed, 78 citations in OpenAlex.
- β-arrestin1 orchestrates endosomal signaling to regulate translational control of circadian light entrainment.Communications biology · 2026Article
- PACAP/PAC1-R activation contributes to hyperalgesia in 6-OHDA-induced Parkinson's disease model rats via promoting excitatory synaptic transmission of spinal dorsal horn neurons.Acta pharmacologica Sinica · 2023Article
- A non-canonical retina-ipRGCs-SCN-PVT visual pathway for mediating contagious itch behavior.Cell reports · 2022Article
- Single cell model for re-entrainment to a shifted light cycle.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Inhibitory responses to retinohypothalamic tract stimulation in the circadian clock of the diurnal rodent Rhabdomys pumilio.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Shorebirds' Longer Migratory Distances Are Associated With LargerFrontiers in psychology · 2021Article
- Ion Channels Controlling Circadian Rhythms in Suprachiasmatic Nucleus Excitability.Physiological reviews · 2020Review
- From clock to functional pacemaker.The European journal of neuroscience · 2020Review
- Acute Blockade of PACAP-Dependent Activity in the Ventromedial Nucleus of the Hypothalamus Disrupts Leptin-Induced Behavioral and Molecular Changes in Rats.Neuroendocrinology · 2020Article
- Neurogenetic basis for circadian regulation of metabolism by the hypothalamus.Genes & development · 2019Review
- Effects of Feeding-Related Peptides on Neuronal Oscillation in the Ventromedial Hypothalamus.Journal of clinical medicine · 2019Article
- Pituitary Adenylate Cyclase-Activating Peptide (PACAP)-Glutamate Co-transmission Drives Circadian Phase-Advancing Responses to Intrinsically Photosensitive Retinal Ganglion Cell Projections by Suprachiasmatic Nucleus.Frontiers in neuroscience · 2019Article
- A-to-I RNA editing enzyme ADAR2 regulates light-induced circadian phase-shift.Scientific reports · 2018Article
- SCN VIP Neurons Are Essential for Normal Light-Mediated Resetting of the Circadian System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Pituitary Adenylate Cyclase-Activating Polypeptide-27 (PACAP-27) in the Thalamic Paraventricular Nucleus Is Stimulated by Ethanol Drinking.Alcoholism, clinical and experimental research · 2018Article
- Not a one-trick pony: Diverse connectivity and functions of the rodent lateral geniculate complex.Visual neuroscience · 2017Review
- High-resolution characterization of a PACAP-EGFP transgenic mouse model for mapping PACAP-expressing neurons.The Journal of comparative neurology · 2016Article
- Association of pituitary adenylate cyclase-activating polypeptide with cognitive decline in mild cognitive impairment due to Alzheimer disease.JAMA neurology · 2015Article
- PACAP modulation of calcium ion activity in developing granule cells of the neonatal mouse olfactory bulb.Journal of neurophysiology · 2015Article
- Pituitary adenylate cyclase activating polypeptide modulates catecholamine storage and exocytosis in PC12 cells.PloS one · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundPrevious studies indicate that light information reaches the suprachiasmatic nucleus (SCN) through a subpopulation of retinal ganglion cells that contain both glutamate and pituitary adenylyl cyclase activating peptide (PACAP). While the role of glutamate in this pathway has been well studied, the involvement of PACAP and its receptors are only beginning to be understood. Speculating that PACAP may function to modulate how neurons in the suprachiasmatic nucleus respond to glutamate, we used electrophysiological and calcium imaging tools to examine possible cellular interactions between these co-transmitters.
resultsExogenous application of PACAP increased both the amplitude and frequency of spontaneous excitatory postsynaptic currents recorded from SCN neurons in a mouse brain slice preparation. PACAP also increased the magnitude of AMPA-evoked currents through a mechanism mediated by PAC1 receptors and the adenylyl cyclase-signalling cascade. This enhancement of excitatory currents was not limited to those evoked by AMPA as the magnitude of NMDA currents were also enhanced by application of PACAP. Furthermore, PACAP enhanced AMPA and NMDA evoked calcium transients while PACAP alone produced very little change in resting calcium in most mouse SCN neurons. Finally, in rat SCN neurons, exogenous PACAP enhanced AMPA evoked currents and calcium transients as well evoked robust calcium transients on its own.
conclusionThe results reported here show that PACAP is a potent modulator of glutamatergic signalling within the SCN in the early night.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.